Howard J Aizenstein
Biographic Data
| ID | 8870712 |
|---|---|
| NAME | Howard J Aizenstein |
| GIVEN NAMES | Howard J |
| FAMILY NAME | Aizenstein |
| SIGNATURE | AIZENSTEIN H J |
| AFFILIATIONS | University of Pittsburgh |
| VERIFIED | No |
| TOTAL WORKS | 6 |
| TOTAL CITATIONS | 1 |
| WORKS AS AUTHOR | 6 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2009 |
| LATEST PUBLICATION YEAR | 2023 |
| H-INDEX | 1 |
Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline
The observed lower dorsomedial thalamus activation may reflect declining familiarity-based working memory and the trans-thalamic executive function pathway in SCD. SCD symptoms may reflect altered neural function and subtle decline of executive function, while Aß load may have an indirect impact on neural function and performance. Self-perceived cognitive decline may serve as a psychological/subjective marker reflecting subtle brain changes
Resting-State Function Connectivity Associated With Being a “Morning-Type” Dementia Caregiver and Having Lower Depression Symptom Severity
Prior research shows that amygdala-posterior cingulate connectivity increases when allocating attention to peripheral aspects of negative emotional stimuli. As such, difficulty with morning activation may relate to the ongoing direction of focus around distressing content; in contrast, morning activity participation may serve to limit focus on distress. Replication and experimental studies are required to confirm these associations and their modi…
Regional Gray Matter Volumes as Related to Psychomotor Slowing in Adults with Type 1 Diabetes
OBJECTIVE: Psychomotor slowing is a common cognitive complication in type 1 diabetes (T1D), but its neuroanatomical correlates and risk factors are unclear. In nondiabetic adults, smaller gray matter volume (GMV) and presence of white matter hyperintensities are associated with psychomotor slowing. We hypothesize that smaller GMV in prefronto-parietal regions explains T1D-related psychomotor slowing. We also inspect the contribution of microvascu…
Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife
OBJECTIVES: The development of Type 1 diabetes mellitus (T1DM) within the first 7 years of life has been linked to poorer cognitive performance. Adults with T1DM have altered functional brain connectivity, but no studies have examined whether earlier age of T1DM onset is associated with functional connectivity later in life. Accordingly, we tested the relationship between age of onset and resting state functional connectivity in a cohort of middl…
Long-Term Survival in Adults 65 Years and Older With White Matter Hyperintensity
OBJECTIVE: White matter hyperintensity (WMH) confers increased mortality risk in patients with cardiovascular diseases. However, little is known about differences in survival times among adults 65 years and older who have WMH and live in the community. To characterize the factors that may reduce mortality risk in the presence of WMH, measures of race, sex, apolipoprotein E4, neuroimaging, and cardiometabolic, physiological, and psychosocial chara…
Gain in Adiposity Across 15 Years is Associated With Reduced Gray Matter Volume in Healthy Women
OBJECTIVE: To test whether current gray matter volume (GMV) covaried with previously obtained longitudinal measures of weight gain-as assessed by increases in body mass index (BMI)-among otherwise healthy postmenopausal women. Cross-sectional results indicate that reduced GMV may be associated with excess body weight. METHODS: Demographic, biometric, and behavioral measures were obtained from 48 women as part of the Pittsburgh Healthy Women Study…
Resting-State Function Connectivity Associated With Being a “Morning-Type” Dementia Caregiver and Having Lower Depression Symptom Severity
Prior research shows that amygdala-posterior cingulate connectivity increases when allocating attention to peripheral aspects of negative emotional stimuli. As such, difficulty with morning activation may relate to the ongoing direction of focus around distressing content; in contrast, morning activity participation may serve to limit focus on distress. Replication and experimental studies are required to confirm these associations and their modi…
Gain in Adiposity Across 15 Years is Associated With Reduced Gray Matter Volume in Healthy Women
OBJECTIVE: To test whether current gray matter volume (GMV) covaried with previously obtained longitudinal measures of weight gain-as assessed by increases in body mass index (BMI)-among otherwise healthy postmenopausal women. Cross-sectional results indicate that reduced GMV may be associated with excess body weight. METHODS: Demographic, biometric, and behavioral measures were obtained from 48 women as part of the Pittsburgh Healthy Women Study…
Long-Term Survival in Adults 65 Years and Older With White Matter Hyperintensity
OBJECTIVE: White matter hyperintensity (WMH) confers increased mortality risk in patients with cardiovascular diseases. However, little is known about differences in survival times among adults 65 years and older who have WMH and live in the community. To characterize the factors that may reduce mortality risk in the presence of WMH, measures of race, sex, apolipoprotein E4, neuroimaging, and cardiometabolic, physiological, and psychosocial chara…
Age of Childhood Onset in Type 1 Diabetes and Functional Brain Connectivity in Midlife
OBJECTIVES: The development of Type 1 diabetes mellitus (T1DM) within the first 7 years of life has been linked to poorer cognitive performance. Adults with T1DM have altered functional brain connectivity, but no studies have examined whether earlier age of T1DM onset is associated with functional connectivity later in life. Accordingly, we tested the relationship between age of onset and resting state functional connectivity in a cohort of middl…
Regional Gray Matter Volumes as Related to Psychomotor Slowing in Adults with Type 1 Diabetes
OBJECTIVE: Psychomotor slowing is a common cognitive complication in type 1 diabetes (T1D), but its neuroanatomical correlates and risk factors are unclear. In nondiabetic adults, smaller gray matter volume (GMV) and presence of white matter hyperintensities are associated with psychomotor slowing. We hypothesize that smaller GMV in prefronto-parietal regions explains T1D-related psychomotor slowing. We also inspect the contribution of microvascu…
Resting-State Function Connectivity Associated With Being a “Morning-Type” Dementia Caregiver and Having Lower Depression Symptom Severity
Prior research shows that amygdala-posterior cingulate connectivity increases when allocating attention to peripheral aspects of negative emotional stimuli. As such, difficulty with morning activation may relate to the ongoing direction of focus around distressing content; in contrast, morning activity participation may serve to limit focus on distress. Replication and experimental studies are required to confirm these associations and their modi…
Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline
The observed lower dorsomedial thalamus activation may reflect declining familiarity-based working memory and the trans-thalamic executive function pathway in SCD. SCD symptoms may reflect altered neural function and subtle decline of executive function, while Aß load may have an indirect impact on neural function and performance. Self-perceived cognitive decline may serve as a psychological/subjective marker reflecting subtle brain changes
Internal Medicine (6 works) · Medicine (6 works) · Internal Medicine (4 works) · Psychology (4 works) · Audiology (3 works) · Cognition (3 works) · Dementia and Cognitive Impairment Research (3 works) · Digit symbol substitution test (3 works) · Functional Brain Connectivity Studies (3 works) · Magnetic resonance imaging (3 works)