Low thalamic activity during a digit-symbol substitution task is associated with symptoms of subjective cognitive decline

Bibliographic Data

ID15518461
AuthorsAkiko Mizuno (0000-0001-5671-8044, University of Pittsburgh, corresponding author), Helmet T Karim (0000-0002-9286-0694, University of Pittsburgh), Maria Ly (0000-0003-3546-0149, University of Pittsburgh), Maria J Ly, Brian J Lopresti (0000-0002-0595-0203, University of Pittsburgh), Ann D Cohen (0000-0001-7395-9624, University of Pittsburgh), Areej A Ali (University of Pittsburgh), Chester A Mathis (0000-0001-9811-0950, University of Pittsburgh), William E Klunk (0000-0001-5512-0251, University of Pittsburgh), Howard Aizenstein (0000-0003-4897-6582, University of Pittsburgh), Howard J Aizenstein, Beth E Snitz (0000-0002-9978-1374, University of Pittsburgh)
Year2023
Volume14
Pages1242822-1242822
Publication date2023-09-06
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2023.1242822
PMID37743995
OpenAlexW4386484346
LanguageEN
References cited76

The observed lower dorsomedial thalamus activation may reflect declining familiarity-based working memory and the trans-thalamic executive function pathway in SCD. SCD symptoms may reflect altered neural function and subtle decline of executive function, while Aß load may have an indirect impact on neural function and performance. Self-perceived cognitive decline may serve as a psychological/subjective marker reflecting subtle brain changes

Audiology · Cognition · Cognitive decline · Dementia · Digit symbol substitution test · Disease · Effects of sleep deprivation on cognitive performance · Pathology · Thalamus · Working memory · Dementia and Cognitive Impairment Research · Functional Brain Connectivity Studies · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Internal Medicine

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