Dorret I Boomsma

Biographic Data

ID918397
NAMEDorret I Boomsma
GIVEN NAMESDorret I
FAMILY NAMEBoomsma
SIGNATUREBOOMSMA D I
AFFILIATIONSVrije Universiteit Amsterdam
ORCID0000-0002-7099-7972
VERIFIEDYes
TOTAL WORKS54
TOTAL CITATIONS72
AUTHOR COUNT54
EDITOR COUNT0
FIRST PUBLICATION YEAR1998
LATEST PUBLICATION YEAR2025
H-INDEX4

  • Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry

    Open AccessAiling Gui, Adam Hollowell et al.ARTICLENature Human Behaviour2025References: 126

    Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking ( N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci. SNP-based heritability was 24.13% (95% confidence intervals = 21.86–26.40) with ~11,900 variants accounting for about 90% of it, suggesting high pol…

  • Associations between common genetic variants and income provide insights about the socio-economic health gradient

    Open AccessHyeokmoon Kweon, Casper A P Burik et al.ARTICLENature Human Behaviour2025Cited by: 2References: 54

    We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1–5% of income variance, with only one fourth due to direct genetic eff…

  • Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes

    Open AccessElham Assary, Jonathan R I Coleman et al.ARTICLENature Human Behaviour2025References: 48

    Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Genome-wide association studies of monozygotic twin differences are conducted through family-based variance analyses, which are more robust to the systemic biases that impact population-based methods. We combined da…

  • Using Instrumental Variables to Measure Causation over Time in Cross-Lagged Panel Models

    Open AccessMadhurbain Singh, Brad Verhulst et al.ARTICLEMultivariate Behavioral Research2024

    Cross-lagged panel models (CLPMs) are commonly used to estimate causal influences between two variables with repeated assessments. The lagged effects in a CLPM depend on the time interval between assessments, eventually becoming undetectable at longer intervals. To address this limitation, we incorporate instrumental variables (IVs) into the CLPM with two study waves and two variables. Doing so enables estimation of both the lagged (i.e., "distal…

  • Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect

    Open AccessSusanne Bruin, Jouke-Jan Hottenga et al.ARTICLEMultivariate Behavioral Research2024

    One type of genotype-environment interaction occurs when genetic effects on a phenotype are moderated by an environment; or when environmental effects on a phenotype are moderated by genes. Here we outline these types of genotype-environment interaction models, and propose a test of genotype-environment interaction based on the classical twin design, which includes observed genetic variables (polygenic scores: PGSs) that account for part of the g…

  • Heritability of adult picky eating in the Netherlands

    Open AccessEmma A Koenders, Laura W Wesseldijk et al.ARTICLEAppetite2024Cited by: 1References: 54

    Adult picky eating (APE), the rejection of familiar and unfamiliar foods leading to a diet with limited variety, is an understudied phenomenon which can have both physical and psychological negative consequences. The aetiology of individual differences in APE is understudied, although there is reason to believe that it is partly heritable. Therefore, we aimed to estimate the heritability of APE with data from the Netherlands Twin Register (n = 80…

  • Familial Clustering of Trends in Aggression

    Open AccessCamiel M van der Laan, Steve Van De Weijer et al.ARTICLEJournal of Quantitative Criminology2023

  • Language and reading impairments are associated with increased prevalence of non-right-handedness

    Open AccessFilippo Abbondanza, Philip S Dale et al.ARTICLEChild Development2023

    Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–…

  • Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus

    Open AccessIain Mathieson, Felix R Day et al.ARTICLENature Human Behaviour2023Cited by: 3References: 70

  • Maximizing the value of twin studies in health and behaviour

    Open AccessFiona A Hagenbeek, Jana S Hirzinger et al.ARTICLENature Human Behaviour2023References: 123

  • Are classrooms equalizers or amplifiers of inequality? A genetically informative investigation of educational performance

    Open AccessKim Stienstra, Antonie Knigge et al.ARTICLEEuropean Sociological Review2023References: 55

    We investigate the influence of the classroom environment on educational performance and its dependency on parental socio-economic status (SES). The classroom environment can have a compensatory effect and decrease educational inequality, in which case the classroom context is more important for children originating from lower SES families. Alternatively, there can be an amplifying effect, in which case the classroom environment is more important…

  • Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

    Open AccessAysu Okbay, Yeda Wu et al.ARTICLENature Genetics2022

    We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…

  • A Note on Jöreskog’s Acde Twin Model: A Solution, Not the Solution

    Open AccessConor V Dolan, Dorret I Boomsma et al.ARTICLEStructural Equation Modeling: A…2022

    The classical twin design is used to decompose phenotypic variance into genetic and environmental variance components. In practice, for reasons of identification, either an ADE or an ACE twin model is fitted, i.e., models with three variance components. Jöreskog proposed to use the Moore-Penrose inverse to estimate the four genetic and environmental variance components in the ACDE twin model. We demonstrate that the variance components thus obtai…

  • Intergenerational transmission of body mass index and associations with educational attainment

    Open AccessHekmat Alrouh, Elsje Van Bergen et al.ARTICLEBMC Public Health2022

    The intergenerational transmission for BMI and EA is mainly predictive within traits. Significant spousal and within person correlations in the parental generation are responsible for the effect of parental EA on offspring BMI. Offspring EA and BMI are further correlated beyond parental influences

  • Genetic and environmental contributions to stability and change in social inhibition across the adolescent and adult life span

    Open AccessRuifang Li-Gao, Dorret I Boomsma et al.ARTICLEDevelopmental Psychology2022

    Feeling inhibited and socially not at ease is reflected in the trait social inhibition (SI). SI is associated with psychopathology that arises in young adulthood, such as anxiety. We aim for a better insight into the genetic and environmental contributions to SI across the life span, and as such examine their contributions to SI stability and change across adolescent and adult life span. We analyzed cohort-sequential longitudinal data from the Ne…

  • Self-rated health when population health is challenged by the Covid-19 pandemic; a longitudinal study

    Open AccessMargot P Van De Weijer, Lianne P De Vries et al.ARTICLESocial Science & Medicine2022Cited by: 4References: 33

    We theorize that the increases in SRH are explained by uninfected individuals evaluating their health more positively than under normal circumstances (partly through social comparison with infected individuals), rather than actual improvements. As the same genes are expressed under different environmental exposures, these results imply no evidence for gene-environment interaction. While different environmental factors might influence SRH at the t…

  • Higher aggression is related to poorer academic performance in compulsory education

    Open AccessEero Vuoksimaa, Richard J Rose et al.ARTICLEJournal of Child Psychology and…2021

    BACKGROUND: To conduct a comprehensive assessment of the association between aggression and academic performance in compulsory education. METHOD: We studied aggression and academic performance in over 27,000 individuals from four European twin cohorts participating in the ACTION consortium (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies). Individual level data on aggression at ages 7-…

  • Associations of sleep with psychological problems and well‐being in adolescence: Causality or common genetic predispositions

    Open AccessMarije C M Vermeulen, Kristiaan B Van Der Heijden et al.ARTICLEJournal of Child Psychology and…2021

    BACKGROUND: Whereas short and problematic sleep are associated with psychological problems in adolescence, causality remains to be elucidated. This study therefore utilized the discordant monozygotic cotwin design and cross-lagged models to investigate how short and problematic sleep affect psychological functioning. METHODS: Adolescent twins (N = 12,803, 13-20 years, 42% male) completed questionnaires on sleep and psychological functioning repea…

  • Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis

    Open AccessLindsay Melhuish Beaupre, Arun K Tiwari et al.ARTICLEFrontiers in Psychiatry2021

    Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many…

  • Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

    Open AccessMelinda C Mills, Felix C Tropf et al.ARTICLENature Human Behaviour2021Cited by: 10References: 81

  • Harmonizing behavioral outcomes across studies, raters, and countries: Application to the genetic analysis of aggression in the Action Consortium

    Open AccessJustin M Luningham, Anne M Hendriks et al.ARTICLEJournal of Child Psychology and…2020

    BACKGROUND: Aggression in children has genetic and environmental causes. Studies of aggression can pool existing datasets to include more complex models of social effects. Such analyses require large datasets with harmonized outcome measures. Here, we made use of a reference panel for phenotype data to harmonize multiple aggression measures in school-aged children to jointly analyze data from five large twin cohorts. METHODS: Individual level agg…

  • Content, diagnostic, correlational, and genetic similarities between common measures of childhood aggressive behaviors and related psychiatric traits

    Open AccessAnne M Hendriks, Hill F Ip et al.ARTICLEJournal of Child Psychology and…2020

    BACKGROUND: Given the role of childhood aggressive behavior (AGG) in everyday child development, precise and accurate measurement is critical in clinical practice and research. This study aims to quantify agreement among widely used measures of childhood AGG regarding item content, clinical concordance, correlation, and underlying genetic construct. METHODS: We analyzed data from 1254 Dutch twin pairs (age 8-10 years, 51.1% boys) from a general p…

  • Parental Age and Offspring Childhood Mental Health: A Multi-Cohort, Population-Based Investigation

    Open AccessMariëlle Zondervan-Zwijnenburg, Sabine A M Veldkamp et al.ARTICLEChild Development2020

    To examine the contributions of maternal and paternal age on offspring externalizing and internalizing problems, this study analyzed problem behaviors at age 10–12 years from four Dutch population-based cohorts (N = 32,892) by a multiple informant design. Bayesian evidence synthesis was used to combine results across cohorts with 50% of the data analyzed for discovery and 50% for confirmation. There was evidence of a robust negative linear relati…

  • Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The Action Biomarker Study

    Open AccessFiona A Hagenbeek, Peter J Roetman et al.ARTICLEFrontiers in Psychiatry2020

    Biomarkers are of interest as potential diagnostic and predictive instruments in personalized medicine. We present the first urinary metabolomics biomarker study of childhood aggression. We aim to examine the association of urinary metabolites and neurotransmitter ratios involved in key metabolic and neurotransmitter pathways in a large cohort of twins (N = 1,347) and clinic-referred children (N = 183) with an average age of 9.7 years. This study…

  • Infant Motor Milestones and Childhood Overweight: Trends over Two Decades in A Large Twin Cohort

    Open AccessSilvia I Brouwer, Ronald P Stolk et al.ARTICLEInternational Journal of…2020

    Comparing children born in 1987 to those born in 2007, we conclude that children nowadays achieve their motor milestones at a later age. This does not however, explain the increasing trend in childhood overweight