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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Bibliographic Data

ID23344403
AuthorseQTLGen eQTLGen (The University of Queensland), Naomi R Wray (0000-0001-7421-3357, Broad Institute, corresponding author), 23andMe 23andMe (Aarhus University), Stephan Ripke (0000-0003-3622-835X, Broad Institute), Manuel Mattheisen (0000-0002-8442-493X, The University of Queensland), Maciej Trzaskowski (0000-0001-8559-6525, The University of Queensland), Enda M Byrne (0000-0002-9491-7797, The University of Queensland), Abdel Abdellaoui (0000-0003-1088-6784, Amsterdam Public Health), Mark J Adams (0000-0002-3599-6018, The University of Adelaide), Esben Agerbo (0000-0002-2849-524X, Aarhus University), Tracy Air (0000-0002-4834-4238, Virginia Commonwealth University), Till F M Andlauer (0000-0002-2917-5889, Munich Cluster for Systems Neurology), Tracy M Air, Till M F Andlauer, Silviu‐Alin Bacanu (0000-0002-4364-1583, Virginia Commonwealth University), Silviu-Alin Bacanu, Marie Bækvad‐Hansen (0000-0002-5881-1776, Statens Serum Institut), Aartjan T F Beekman (0000-0003-2382-1410, GGZ inGeest), Marie Bækvad-Hansen, Aartjan F T Beekman, Eugene Binder (0000-0001-7088-6618, Emory University), Tim B Bigdeli (0000-0003-2215-5946, Genetics and IVF Institute), Elisabeth B Binder, Douglas Blackwood (Aarhus University), Douglas R H Blackwood, Julien Bryois (0000-0002-4747-2166, Statens Serum Institut), Henriette N Buttenschon (0000-0003-3800-9169, European Bioinformatics Institute), Jonas Bybjerg-Grauholm (0000-0003-1705-4008, Statens Serum Institut), Na Cai (0000-0001-7496-2075, European Bioinformatics Institute), Enrique Castelao (0000-0003-1966-3683, University Hospital of Lausanne), Jane Christensen (0000-0002-0009-2991, King's College London), Jane Hvarregaard Christensen, Toni‐Kim Clarke (0000-0002-7745-6351, QIMR Berghofer Medical Research Institute), Toni-Kim Clarke, Jonathan R I Coleman (0000-0002-6759-0944, The University of Queensland), Jonathan I R Coleman, Lucia Colodro-Conde (0000-0002-9004-364X, QIMR Berghofer Medical Research Institute), Baptiste Couvy‐Duchesne (0000-0002-0719-9302, The University of Queensland), Baptiste Couvy-Duchesne, Nick Craddock (0000-0003-2171-0610, University of North Carolina at Chapel Hill), Gregory E Crawford (0000-0001-6106-2772, Broad Institute), Cheynna Crowley (0000-0002-4926-2875, University of North Carolina at Chapel Hill), Cheynna A Crowley, Hassan S Dashti (0000-0002-1650-679X, Broad Institute), Gail Davies (0000-0002-6811-0885, University of Bonn), Ian J Deary (0000-0002-1733-263X, QIMR Berghofer Medical Research Institute), Franziska Degenhardt (0000-0002-1685-8904, University of Bonn), Eske M Derks (0000-0002-6292-6883, QIMR Berghofer Medical Research Institute), Neşe Direk (0000-0002-3631-5990, Broad Institute), Conor V Dolan (0000-0002-2496-8492, King's College London), Erin C Dunn (0000-0003-1413-3229, Broad Institute), Thalia C Eley (0000-0001-6458-0700, King's College London), Nicholas Eriksson (0000-0003-2031-2872, University of British Columbia), Valentina Escott‐Price (0000-0003-1784-5483, Harvard University), Valentina Escott-Price, Farnush Hassan Farhadi Kiadeh (University of Bonn), Hilary K Finucane (0000-0003-3864-9828, Harvard University), J Frank (0000-0003-4867-9465, Trinity College Dublin), Andreas J Forstner (0000-0002-1876-6368, University of Bonn), Héléna A Gaspar (0000-0002-5540-2707, University of North Carolina at Chapel Hill), Michael Gill (0000-0002-6163-7289, Johns Hopkins University), Paola Giusti‐Rodríguez (0000-0002-1921-1305, University of North Carolina at Chapel Hill), Paola Giusti-Rodríguez, Fernando S Goes (0000-0001-6262-8264, Johns Hopkins University), Scott D Gordon (0000-0001-7623-328X, QIMR Berghofer Medical Research Institute), John Grove (0000-0003-2284-5744, Aarhus University), Lynsey S Hall (0000-0002-0624-5303, Statens Serum Institut), Eilis Hannon (0000-0001-6840-072X, University of Exeter), Thiago Freitas Hansen (0000-0001-6703-7762, The University of Sydney), Christine Søholm Hansen (0000-0002-7518-4663, Statens Serum Institut), Thomas F Hansen (0000-0002-3796-7552), Stefan Herms (0000-0002-2786-8200, University of Bonn), Ian B Hickie (0000-0001-8832-9895, The University of Sydney), Per Hoffmann (0000-0002-6573-983X, Roche (Switzerland)), Georg Homuth (0000-0001-6839-0605, Universität Greifswald), Carsten Horn (0009-0003-0414-8803, Statens Serum Institut), Jouke-Jan Hottenga (0000-0002-5668-2368, Cleveland Clinic), David M Hougaard (0000-0001-5928-3517, Statens Serum Institut), Ming Hu (0000-0003-2583-1161, Cleveland Clinic), Craig Hyde (0000-0002-6939-287X, Pfizer (United States)), Craig L Hyde, Marcus Ising (0000-0001-5421-5777, Max Planck Institute of Psychiatry), Rick Jansen (0000-0002-3333-6737, Kaiser Permanente), Fulai Jin (0000-0003-0025-4337, University of Southern California), Eric Jorgenson (0000-0002-5829-8191, Brigham and Women's Hospital), James A Knowles (University of Southern California), Isaac S Kohane (0000-0003-2192-5160, Brigham and Women's Hospital), Julia Kraft (0000-0001-7306-1179, University of Copenhagen), Warren W Kretzschmar (0000-0002-2575-0807, SIB Swiss Institute of Bioinformatics), Jesper Krogh (0000-0003-4834-6724, University of Copenhagen), J Michael Lane (0000-0001-6101-2855, Broad Institute), Zoltan Kutalik (0000-0001-8285-7523, SIB Swiss Institute of Bioinformatics), Yihan Li (0000-0002-1147-5787, University of North Carolina at Chapel Hill), Yun Li (0000-0001-8225-4554, University of North Carolina at Chapel Hill), Penelope A Lind (0000-0002-3887-2598, QIMR Berghofer Medical Research Institute), Xiaoxiao Liu (0000-0001-6065-3458, Case Western Reserve University), Leina Lu (0000-0001-9878-1068, Johns Hopkins University), Donald J MacIntyre (0000-0001-6963-1335, The University of Queensland), Robert Maier (0000-0002-3044-090X, The University of Queensland), Dean F MacKinnon (0000-0002-3212-437X, University of Bonn), Robert M Maier, Wolfgang Maier (0000-0003-3305-725X, University of Bonn), Jonathan Marchini (0000-0003-0610-8322, University of Oxford), Hamdi Mbarek (0000-0002-1108-0371, King's College London), Patrick J Mcgrath (0000-0002-9568-2571, QIMR Berghofer Medical Research Institute), Patrick Mcgrath (0000-0002-8145-5511), Peter Mcguffin (0000-0002-9888-2907, The University of Queensland), Sarah E Medland (0000-0003-1382-380X, QIMR Berghofer Medical Research Institute), Divya Mehta (0009-0008-6674-8480, Queensland University of Technology), Christel M Middeldorp (0000-0002-6218-0428, The University of Queensland), Evelin Mihailov (University of Tartu), Yuri Milaneschi (0000-0002-3697-6617, University of Exeter), Lili Milani (0000-0002-5323-3102, Johns Hopkins University), Jonathan Mills (0000-0003-1115-3224, The University of Queensland), Jonathan Mill, Francis M Mondimore (0000-0003-1491-9563, University of British Columbia), Grant W Montgomery (0000-0002-4140-8139, The University of Queensland), Sara Mostafavi (0000-0003-4698-1177, University of British Columbia), Niamh Mullins (0000-0001-8021-839X, University of British Columbia), Matthias Nauck (0000-0002-6678-7964), Bernard Ng (0000-0002-0126-1275), Michel G Nivard (0000-0003-2015-1888), Dale R Nyholt (0000-0001-7159-3040), Paul F O’reilly (0000-0001-7515-0845), Hogni Oskarsson, Michael J Owen (0000-0002-8750-1064), Jodie N Painter (0000-0002-4992-2458), Carsten Bøcker Pedersen (0000-0003-2077-8533), Marianne Giørtz Pedersen (0000-0002-9707-5441), Roseann E Peterson (0000-0001-6402-849X), Erik Pettersson (0000-0003-0149-9002), Wouter J Peyrot (0000-0001-7954-8383), Giorgio Pistis (0000-0002-4525-4608), Danielle Posthuma (0000-0001-7582-2365), Shaun M Purcell (0000-0002-7402-5812), Jorge A Quiróz (0000-0001-7254-366X), Per Qvist (0000-0002-0750-0089), John P Rice (0000-0002-2765-3824), Brien P Riley (0000-0002-2408-8268), Margarita Rivera (0000-0003-4717-1045), Saira Saeed Mirza (0000-0002-0973-2246), Richa Saxena (0000-0002-6634-2041), Robert Schoevers, Eva C Schulte (0000-0003-3105-5672), Ling Shen (0000-0001-5965-3303), Jianxin Shi (0000-0002-7717-0863), Stanley I Shyn (0000-0002-5962-1237), Engilbert Sigurdsson (0000-0001-9404-7982), Grant B C Sinnamon, Johannes H Smit (0000-0002-2062-8378), Daniel J Smıth (0000-0002-2267-1951), Daniel J Smith (0000-0001-6776-9971), Hreinn Stefánsson (0000-0002-9331-6666), Stephen Steinberg (0000-0001-7726-5152), Craig A Stockmeier (0000-0003-1861-1013), Fabian Streit, Jana Strohmaier, Katherine E Tansey, Henning Teismann (0000-0001-5807-5572), Alexander Teumer (0000-0002-8309-094X), Wesley Thompson, Pippa A Thomson, Thorgeir E Thorgeirsson (0000-0002-5149-7040), Chao Tian (0000-0003-4971-770X), Matthew Traylor (0000-0001-6624-8621), Jens Treutlein, Vassily Trubetskoy (0000-0003-3074-728X), André G Uitterlinden (0000-0002-7276-3387), Daniel Umbricht (0000-0003-0272-2157), Sandra Van der Auwera, Albert M van Hemert (0000-0003-3421-355X), Alexander Viktorin, Peter M Visscher (0000-0002-2143-8760), Yunpeng Wang (0009-0002-5411-9202), Bradley T Webb (0000-0002-0576-5366), Shantel Marie Weinsheimer, Jürgen Wellmann (0000-0003-3635-8584), Gonneke Willemsen (0000-0003-3755-0236), Stephanie H Witt, Yang Wu (0000-0002-0014-603X), Hualin S Xi, Jian Yang (0000-0003-2001-2474), Futao Zhang, Volker Arolt (0000-0002-2445-9778), Bernhard T Baune (0000-0001-6548-426X), Klaus Berger (0000-0001-8966-3684), Dorret I Boomsma (0000-0002-7099-7972), Sven Cichon, Udo Dannlowski (0000-0002-0623-3759), E C J de Geus, J Raymond DePaulo (0000-0001-9221-9226), Enrico Domenici, Katharina Domschke (0000-0002-2550-9132), Tõnu Esko (0000-0003-1982-6569), Hans J Grabe (0000-0003-3684-4208), Steven P Hamilton, Caroline Hayward (0000-0002-9405-9550), Andrew C Heath (0000-0002-9414-6857), David A Hinds (0000-0002-4911-803X), Kenneth S Kendler (0000-0001-8689-6570), Stefan Kloiber (0000-0002-6838-4114), Glyn Lewis (0000-0001-5205-8245), Qingqin S Li (0000-0003-4182-4535), Susanne Lucae (0000-0001-6263-3485), Pamela F A Madden, Patrik K Magnusson, Nicholas G Martins (0000-0003-4069-8020), Nicholas G Martin, Andrew M Mcintosh (0000-0002-0198-4588), Andres Metspalu (0000-0002-3718-796X), Ole Mors (0000-0002-5660-0393), Preben Bo Mortensen (0000-0002-5230-9865), Bertram Müller-Myhsok, Merete Nordentoft (0000-0003-4895-7023), Markus M Nöthen (0000-0002-8770-2464), Michael C O’Donovan, Sara A Paciga, Nancy L Pedersen (0000-0001-8057-3543), Brenda W J H Penninx (0000-0001-7779-9672), Roy H Perlis (0000-0002-5862-6757), Diana Porteous (0000-0003-1249-6106), James B Potash (0000-0002-5802-8079), Martin Preisig (0000-0001-5689-4259), Marcella Rietschel, Catherine Schaefer, Thomas G Schulze, Jordan W Smoller (0000-0002-0381-6334), Kári Stefánsson (0000-0003-1676-864X), Henning Tiemeier (0000-0002-4395-1397), Rudolf Uher (0000-0002-2998-0546), Henry Völzke (0000-0001-7003-399X), Myrna M Weissman (0000-0003-3490-3075), Thomas Werge (0000-0003-1829-0766), Ashley R Winslow, Cathryn M Lewis (0000-0002-8249-8476), Douglas F Levinson, Gerome Breen (0000-0003-2053-1792), Anders D Børglum (0000-0001-8627-7219), Patrick F Sullivan (0000-0002-6619-873X)
Year2018
Volume50
Issue5
Pages668-681
Publication date2018-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueNature Genetics (JOURNAL)
Journal identifiersISSN: 1061-4036 • E-ISSN: 1546-1718
PublisherSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1038/s41588-018-0090-3
PMID29700475
OpenAlexW2738082385
LanguageEN
Citations received98
References cited111

Association (psychology) · Biology · Computational biology · Evolutionary biology · Gene · Genetic architecture · Genetic association · Genome-wide association study · Genotype · Quantitative trait locus · Single-nucleotide polymorphism · BRCA gene mutations in cancer · Genetic Associations and Epidemiology · Genetics · Genetics and Neurodevelopmental Disorders · Psychology

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Unique citing works98
Citations per year12,25
Citation span2018 - 2026 (9)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 88

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