An atlas of genetic correlations across human diseases and traits
Bibliographic Data
| ID | 23347643 |
|---|---|
| Authors | ReproGen Consortium, Brendan Bulik‐Sullivan (0000-0001-9402-7279, Broad Institute, corresponding author), Brendan Bulik-Sullivan, Hilary K Finucane (0000-0003-3864-9828, Massachusetts Institute of Technology, corresponding author), Verneri Anttila (0000-0002-0073-4675, Broad Institute), Po‐Ru Loh (0000-0001-5542-9064, Broad Institute), Laramie E Duncan (0000-0003-1131-661X, Broad Institute), Alexander Gusev (0000-0002-8699-9112, Harvard University), Felix R Day (0000-0003-3789-7651, University of Cambridge), Po-Ru Loh, Earl B Robinson (0000-0003-2314-2792, Broad Institute), Laramie Duncan, John R B Perry (0000-0001-6483-3771, University of Cambridge), Nick Patterson (0000-0003-0302-684X, Broad Institute), Elise B Robinson, Mark J Daly (0000-0002-0949-8752, Broad Institute), Alkes L Price (0000-0002-2971-7975, Broad Institute, corresponding author), Benjamin M Neale (0000-0003-1513-6077, Broad Institute, corresponding author) |
| Year | 2015 |
| Volume | 47 |
| Issue | 11 |
| Pages | 1236-1241 |
| Publication date | 2015-11-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Nature Genetics (JOURNAL) |
| Journal identifiers | ISSN: 1061-4036 • E-ISSN: 1546-1718 |
| Publisher | Springer Science and Business Media LLC (PUBLISHER) |
| DOI | 10.1038/ng.3406 |
| PMID | 26414676 |
| OpenAlex | W2195783463 |
| Language | EN |
| Citations received | 96 |
| References cited | 58 |
Biology · Correlation · Educational attainment · Genetic association · Genetic correlation · Genetic variation · Genome-wide association study · Genotype · Sample size determination · Single-nucleotide polymorphism · Statistics · Trait · Autism Spectrum Disorder Research · Computer Science · Genetic Associations and Epidemiology · Genetics · Genetics and Neurodevelopmental Disorders
Shared Genetics and Causality Between Decaffeinated Coffee Consumption and Neuropsychiatric Diseases
Association among attention-deficit hyperactivity disorder, restless legs syndrome, and peripheral iron status
Markers of Psychological Differences and Social and Health Inequalities
Prenatal programming of developmental trajectories for obesity risk and early pubertal timing
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
The nature of nurture
Genome-wide association study identifies 74 loci associated with educational attainment
Heart Disease and Stroke Statistics—2023 Update
An Expanded View of Complex Traits
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Years of GWAS Discovery
Identification of common genetic risk variants for autism spectrum disorder
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Genes Related to Education Predict Frailty Among Older Adults in the United States
Maternal Psychological Problems During Pregnancy and Child Externalizing Problems
Shared genetic architecture of psychiatric disorders and hemorrhoidal disease
Determination of genetic correlation between tobacco smoking and coronary artery disease
Association of Barrett's esophagus with obstructive sleep apnea syndrome
Exploring the relationship and shared mechanisms of major depressive disorder and diabetic kidney disease
Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males
Are Alzheimer's and coronary artery diseases genetically related to longevity
Aberrant Dynamic Connectivity for Fear Processing in Anorexia Nervosa and Body Dysmorphic Disorder
A Unifying Theory for Autism
Genetic analyses of the bidirectional associations between common mental disorders and asthma
Causal effects of potential risk factors on postpartum depression
The Genetic Intersection of Neurodevelopmental Disorders and Shared Medical Comorbidities – Relations that Translate from Bench to Bedside
Depression and hepatobiliary diseases
Genetic Pleiotropy and Causal Pathways Linking Glycemic Traits to Asthma
Mothers of small-bodied children and fathers of vigorous sons live longer
Sarcopenia-related traits and 10 digestive system disorders
The “Golden Age” of Behavior Genetics
Pubertal maturation is independent of family structure but daughters of divorced (but not dead) fathers start reproduction earlier
An examination of potential mediators of the relationship between polygenic scores of BMI and waist circumference and phenotypic adiposity
Research Review
Convergent genetic pathways linking neuropsychiatric and ocular disorders in children
The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls
Examining the bidirectional association between emotion recognition and social autistic traits using observational and genetic analyses
On the importance of parenting in externalizing disorders
Using Polygenic Scores in Social Science Research
Polygenic Scores for Plasticity
Sociogenomics in the 21st century
Limited common origins of multiple adult health-related behaviors
Lessons in adjusting for genetic confounding in population research on education and health
Causal relationships between plasma protein ratios and lung cancer risk
Developmental pathways linking obesity risk and early puberty
Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits
Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample
Personality traits relate to chronotype at both the phenotypic and genetic level
Genetic Endowments and Wealth Inequality
Birth Weight and Development
Association between birth weight and educational attainment
Implications of the genomic revolution for education research and policy
Genome-Wide Heritability Estimates for Family Life Course Complexity
Understanding Internal Migration
Genome-wide association study identifies 48 common genetic variants associated with handedness
Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Shared genetic architectures of educational attainment in East Asian and European populations
Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome
Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
Nationwide health, socio-economic and genetic predictors of Covid-19 vaccination status in Finland
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Associations between common genetic variants and income provide insights about the socio-economic health gradient
Analysis of Sex-Specific Gene-by-Cohort and Genetic Correlation-by-Cohort Interaction in Educational and Reproductive Outcomes Using the UK Biobank Data
Education, Smoking, and Cohort Change
Pigeon
Beyond the factor indeterminacy problem using genome-wide association data
Brain structure, phenotypic and genetic correlates of reading performance
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Genomic evidence consistent with antagonistic pleiotropy may help explain the evolutionary maintenance of same-sex sexual behaviour in humans
Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits
Genetic associations between non-cognitive skills and academic achievement over development
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia
Neurobehavioural characterisation and stratification of reinforcement-related behaviour
The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation
A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data
GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture
Genetic loci shared between major depression and intelligence with mixed directions of effect
Using genetics for social science
Socio-economic status is a social construct with heritable components and genetic consequences
Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits
The genetic landscape of neuro-related proteins in human plasma
Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression
The New Genetics of Sexuality
Methodology for Genetic Studies of Twins and Families
Intelligence and educational achievement
Mendelian randomization
Common SNPs explain a large proportion of the heritability for human height
Gcta
Potential for primary prevention of Alzheimer's disease
‘Mendelian randomization’
Causal Diagrams for Epidemiologic Research
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Trends in Cigarette Smoking in the United States
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
The projected effect of risk factor reduction on Alzheimer's disease prevalence
A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors
Psychiatric Comorbidities of Female Inpatients With Eating Disorders
| Unique citing works | 96 |
|---|---|
| Citations per year | 9,6 |
| Citation span | 2016 - 2026 (11) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 92 |