Polygenic Scores for Plasticity
A New Tool for Studying Gene–Environment Interplay
Dados Bibliográficos
| ID | 21030641 |
|---|---|
| Autores | R A Johnson (0000-0003-2475-6622, Georgetown University), Ramina Sotoudeh (0000-0002-1716-017X, Nuffield College, University of Oxford, Oxford, UK), D Conley (0000-0002-5174-7222, Princeton University, autor correspondente) |
| Ano | 2022 |
| Volume | 59 |
| Fascículo | 3 |
| Páginas | 1045-1070 |
| Data de publicação | 2022-06-01 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Demography (JOURNAL) |
| Identificadores do periódico | ISSN: 0070-3370 • E-ISSN: 1533-7790 |
| Editora | Duke University Press (PUBLISHER • US) |
| DOI | 10.1215/00703370-9957418 |
| PMID | 35553650 |
| OpenAlex | W4280503748 |
| Idioma | EN |
| Citações recebidas | 12 |
| Referências citadas | 44 |
Fertility, health, education, and other outcomes of interest to demographers are the product of an individual's genetic makeup and their social environment. Yet, gene × environment (G×E) research deploys a limited toolkit on the genetic side to study the gene–environment interplay, relying on polygenic scores (PGSs) that reflect the influence of genetics on levels of an outcome. In this article, we develop a genetic summary measure better suited for G×E research: variance polygenic scores (vPGSs), which are PGSs that reflect genetic contributions to plasticity in outcomes. First, we use the UK Biobank (N ∼ 408,000 in the analytic sample) and the Health and Retirement Study (N ∼ 5,700 in the analytic sample) to compare four approaches to constructing PGSs for plasticity. The results show that widely used methods for discovering which genetic variants affect outcome variability fail to serve as distinctive new tools for G×E. Second, using the PGSs that do capture distinctive genetic contributions to plasticity, we analyze heterogeneous effects of a UK education reform on health and educational attainment. The results show the properties of a useful new tool for population scientists studying the interplay of nature and nurture and for population-based studies that are releasing PGSs to applied researchers
Biobank · Biology · Nature versus nurture · Population · Sociology · Birth, Development, and Health · Cognitive Abilities and Testing · Demography · Genetic Associations and Epidemiology · Genetics · Psychology
Does Expanding Free Secondary Education Moderate the Relationship Between Genes and Socioeconomic Outcomes? Evidence from the Education Act of 1944 in England
Exploring the Fetal Origins Hypothesis Using Genetic Data
Detecting genetic heterogeneities in response to trauma
Wrestling with Social and Behavioral Genomics
Genetics for ‘equality’? The politics of knowledge production in educational genomics
The development of body mass index from adolescence to adulthood
Gene-by-peer-environment interaction effects on cigarette, alcohol, and marijuana use among US high school students of European Ancestry
Interaction of family SES with children’s genetic propensity for cognitive and noncognitive skills
Separating Scarring Effect and Selection of Early-Life Exposures With Genetic Data
Analysis of Sex-Specific Gene-by-Cohort and Genetic Correlation-by-Cohort Interaction in Educational and Reproductive Outcomes Using the UK Biobank Data
New Data Sources for Demographic Research
Pigeon
Genetic studies of body mass index yield new insights for obesity biology
An atlas of genetic correlations across human diseases and traits
The nature of nurture
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
An Expanded View of Complex Traits
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry
Gene × Environment Interaction Studies Have Not Properly Controlled for Potential Confounders
Interactions between Polygenic Scores and Environments
Interplay between heritability of smoking and environmental conditions? A comparison of two birth cohorts
Schools as Moderators of Genetic Associations with Life Course Attainments
Differential vulnerability to neighbourhood disorder
Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index
The Genome-Wide Influence on Human BMI Depends on Physical Activity, Life Course, and Historical Period
Genes, Gender Inequality, and Educational Attainment
Gene-environment interactions between education and body mass
Genetic influence on social outcomes during and after the Soviet era in Estonia
Genotype-environment interaction and sociology
What Is Your Estimand? Defining the Target Quantity Connects Statistical Evidence to Theory
Education, Smoking, and Cohort Change
Lifetime Socioeconomic Status, Historical Context, and Genetic Inheritance in Shaping Body Mass in Middle and Late Adulthood
Trends in the Genetic Influences on Smoking
Socio-Genomic Research Using Genome-Wide Molecular Data
Gene by Social Context Interactions for Number of Sexual Partners among White Male Youths
| Obras citantes distintas | 12 |
|---|---|
| Citações por ano | 3 |
| Intervalo de citações | 2022 - 2025 (4) |
| Velocidade de citação | recent |
| Altamente citado | Não |
| Tipos de citação | Neutras: 11 |