Steve Horvath

Dados Biográficos

ID1738478
NOMESteve Horvath
PRENOMESSteve
SOBRENOMEHorvath
ASSINATURAHORVATH S
AFILIAÇÕESUniversity of California, Los Angeles
ORCID0000-0002-4110-3589
VERIFICADOSim
TOTAL DE OBRAS7
TOTAL DE CITAÇÕES0
OBRAS COMO AUTOR7
OBRAS COMO EDITOR0
PRIMEIRO ANO DE PUBLICAÇÃO2008
ANO MAIS RECENTE DE PUBLICAÇÃO2024
ÍNDICE H0

  • Grandparents' educational attainment is associated with grandchildren's epigenetic-based age acceleration in the National Growth and Health Study

    Open AccessAgus Surachman, Elissa Hamlat et al.ARTICLESocial Science & Medicine2024Referências: 52

    We examined three generations (grandparents, mothers, and grandchildren) to assess the association between grandparents' educational attainment and their grandchildren's epigenetic-based age acceleration and whether the association was mediated by parental educational attainment and mothers' life course health-related factors. Mothers were recruited to the NHLBI Growth and Health Study at 9-10 years and followed for 10 years (1987-1998). Mothers …

  • Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men

    Cuicui Wang, Dawn L DeMeo et al.ARTICLEPsychosomatic Medicine2023

    OBJECTIVE: Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among older individuals who are more versus less optimistic. METHODS: Using cross-sectional data from two population-based cohorts of women with diverse races/ethnicities ( n = 3816) and men (only White, n …

  • DNA methylation GrimAge strongly predicts lifespan and healthspan

    Open AccessAke T Lu, Austin Quach et al.ARTICLEAging2019

    Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly …

  • DNA methylation-based biomarkers and the epigenetic clock theory of ageing

    Open AccessSteve Horvath, Kenneth RajARTICLENature Reviews Genetics2018

  • An epigenetic biomarker of aging for lifespan and healthspan

    Open AccessM E Levine, Ake T Lu et al.ARTICLEAging2018

    Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. U…

  • DNA methylation age of human tissues and cell types

    Open AccessSteve HorvathARTICLEGenome Biology2013

  • Wgcna

    Open AccessPeter Langfelder, Steve HorvathARTICLEBMC Bioinformatics2008

    BACKGROUND: Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns among genes across microarray samples. Weighted correlation network analysis (WGCNA) can be used for finding clusters (modules) of highly correlated genes, for summarizing such clusters using the module eigengene or an intramodular…