Grandparents' educational attainment is associated with grandchildren's epigenetic-based age acceleration in the National Growth and Health Study

Dados Bibliográficos

ID4598590
AutoresAgus Surachman (0000-0001-7474-9450, Drexel University, autor correspondente), Elissa Hamlat (0000-0001-7339-8222, University of California, San Francisco), Anthony S Zannas (0000-0002-6897-9652, University of North Carolina at Chapel Hill), Steve Horvath (0000-0002-4110-3589, University of California, Los Angeles), Barbara Laraia (0000-0002-0493-2900, University of California, Berkeley), Elissa Epel (0000-0002-8004-2571, University of California, San Francisco, autor correspondente)
Ano2024
Volume355
Páginas117142
Data de publicação2024-08-01
Open AccessSim
TipoARTICLE
PeriódicoSocial Science & Medicine (JOURNAL)
Identificadores do periódicoISSN: 0277-9536 • E-ISSN: 1873-5347
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.socscimed.2024.117142
PMID39106784
OpenAlexW4400620416
IdiomaEN
Citações recebidas1
Referências citadas52

We examined three generations (grandparents, mothers, and grandchildren) to assess the association between grandparents' educational attainment and their grandchildren's epigenetic-based age acceleration and whether the association was mediated by parental educational attainment and mothers' life course health-related factors. Mothers were recruited to the NHLBI Growth and Health Study at 9-10 years and followed for 10 years (1987-1998). Mothers were then re-contacted three decades later (ages 37-42) to participate in the National Growth and Health Study (NGHS), and health information from their youngest child (i.e., grandchildren; N = 241, ages 2-17) was collected, including their saliva samples to calculate epigenetic age. Five epigenetic-based age acceleration measures were included in this analysis, including four epigenetic clock age accelerations (Horvath, Hannum, GrimAge, and PhenoAge) and DunedinPACE. Grandparents reported their highest education during the initial enrollment interviews. Parental educational attainment and mothers' life course health-related factors (childhood BMI trajectories, adult cardiovascular health behavioral risk score, and adult c-reactive protein) are included as mediators. Grandparents' education was significantly associated with Horvath age acceleration (b = -0.32, SE = 0.14, p = 0.021). Grandchildren with college-degree grandparents showed significantly slower Horvath age accelerations than those without college degrees. This association was partially mediated by parental education and mothers' health-related factors, especially adult cardiovascular health behavioral risk score and CRP, but not mothers' childhood BMI trajectory. This ability to conserve the speed of biological aging may have considerable consequences in shaping health trajectories across the lifespan

Biology · Developmental psychology · Educational attainment · Epigenetics · Grandparent · Life course approach · Longitudinal study · Young adult · Birth, Development, and Health · Demography · Health disparities and outcomes · Health, Environment, Cognitive Aging · Medicine · Psychology · Genetics · Gerontology

Ferramentas

Abrir DOIOpen Access