Guangxia ZHANG

Dados Biográficos

ID8916951
NOMEGuangxia ZHANG
PRENOMESGuangxia
SOBRENOMEZHANG
ASSINATURAZHANG G
AFILIAÇÕESZhejiang Normal University
VERIFICADONão
TOTAL DE OBRAS3
TOTAL DE CITAÇÕES0
TOTAL COMO AUTOR3
TOTAL COMO EDITOR0
PRIMEIRO ANO DE PUBLICAÇÃO2013
ANO MAIS RECENTE DE PUBLICAÇÃO2018
ÍNDICE H0

  • On the spatial relationship between ecosystem services and urbanization

    Open AccessYan Zhang, Yanfang Liu et al.ARTICLEThe Science of The Total…2018

  • The Effects of Long-term Exposure to Bisphenol-A on Fear Memory of Adult Mice

    Qin Zhang, Xiaohong Xu et al.ARTICLEActa Psychologica Sinica2014

    摘要

  • The Effects of Environmental Endocrine Disrupter Bisphenol A on Learning-memory and Synaptic Structure of Adult Mice

    Xingyi Liu, Xiaohong Xu et al.ARTICLEActa Psychologica Sinica2013

    摘要: 双酚A (bisphenol, BPA) 是一种广泛存在的环境内分泌干扰物, 它可与雌激素受体结合干扰内源性雌激素对中枢神经系统的调控作用。本研究通过将10周龄小鼠灌胃染毒BPA (0.4、4、40 mg/kg/day)3个月, 研究长期BPA暴露对成年小鼠记忆行为和突触可塑性的影响。开场行为测试结果表明, BPA (0.4、4、40 mg/kg/day)增加雄性的站立次数和理毛频率, BPA (4 mg/kg/day)却显著减少雌鼠的站立次数。水迷宫和被动回避行为模型检测显示, BPA主要损伤雄鼠的空间学习记忆和被动回避记忆。通过制备海马CA1区超薄切片后, 电镜观测发现, BPA (0.4、40 mg/kg/day) 暴露降低雄鼠海马CA1区突触数密度, 缩短雄鼠突触前活性带长度, 减小雄鼠突触后致密体(PSD)厚度, 增加雄鼠突触间隙宽度。进一步用Western blot方法检测突触前、后的标志性蛋白Synapsin I和PSD95以及兴奋性氨基酸NMDA受体NR1亚基和A…