The challenges of evaluating environmental interventions to increase population levels of physical activity
The case of the UK National Cycle Network
Dados Bibliográficos
| ID | 11171978 |
|---|---|
| Autores | Deborah A Lawlor (0000-0002-6793-2262, University of Bristol, autor correspondente), A R Ness (University of Bristol), A M Cope (Sustrans), A Davis (0000-0001-9871-4527, Sustrans), P Insall (Sustrans), C Riddoch (University of Bristol) |
| Ano | 2003 |
| Volume | 57 |
| Fascículo | 2 |
| Páginas | 96-101 |
| Data de publicação | 2003-02-01 |
| Peer Reviewed | Sim |
| Open Access | Não |
| Tipo | ARTICLE |
| Periódico | Journal of Epidemiology and Community Health (JOURNAL) |
| Identificadores do periódico | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Editora | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.57.2.96 |
| PMID | 12540683 |
| OpenAlex | W2119809540 |
| Idioma | EN |
| Citações recebidas | 19 |
| Referências citadas | 15 |
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I interferon (IFN-I) responsive microglia population that expanded with this developmental stressor. Using the marker gene IFITM3 we found that IFN-I responsive microglia were engulfing whole neurons. Loss of IFN-I signaling ( Ifnar1 -/- ) resulted in dysmorphic ‘bubble’ microglia with enlarged phagolysosomal compartments. We also observed a reduction in dead cells and an accumulation of neurons with double strand DNA breaks, a marker of cell stress. Conversely, IFN-I gain of function in zebrafish was sufficient to drive microglial engulfment of whole neurons. We identified IFITM3+ microglia in two murine disease models: SARS-CoV-2 infection and the 5xFAD model of Alzheimer’s disease. These data reveal a novel role for IFN-I signaling in regulating efficient neuronal clearance by microglia
Biology · Gene · Immune system · Inflammation · Innate immune system · Microglia · Population · Somatosensory system · Zebrafish · Cell Biology · Genetics · Immunology · Inflammation biomarkers and pathways · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neuroscience
Social networks and health
Evidence for public health policy on inequalities
Building environment to promote health
Why do friendships matter for survival
Commuting by Bicycle
Cycling for transport and public health
Healthy urban planning in European cities
Health, science, and complexity
Investigating the effects of a shared bike for tourism use on the tourist experience and its consequences
From exports to exercise
Residents' diverse perspectives of the impact of neighbourhood renewal on quality of life and physical activity engagement
Bicyclist commuters’ choice of on-street versus off-street route segments
The effects of changes to the built environment on the mental health and well-being of adults
Urban Planning for Healthy Cities
The population effect of crime and neighbourhood on physical activity
The physical environment and physical activity
Impact of academic exposure on health status of university students
Variation in biological status among Polish males and underlying socio-economic factors
To the West and East of Interstate-35
Commuting in Transit Versus Automobile Neighborhoods
All-Cause Mortality Associated With Physical Activity During Leisure Time, Work, Sports, and Cycling to Work
A Meta-Analysis of Physical Activity in the Prevention of Coronary Heart Disease
Pathways of disadvantage? Walking as a mode of transport among low-income mothers
Self reported physical activity, public health, and perceived environment
The right answer for the wrong question
| Obras citantes distintas | 19 |
|---|---|
| Citações por ano | 0,86 |
| Intervalo de citações | 2004 - 2021 (18) |
| Velocidade de citação | historical |
| Altamente citado | Não |
| Tipos de citação | Neutras: 15 |