The effects of Jiawei Duhuo Jisheng mixture on Wnt/β-catenin signaling pathway in the synovium inflamed by knee osteoarthritis

An in vitro and in vivo experiment

Dados Bibliográficos

ID14728013
AutoresQiyun Shi (0000-0002-7144-2370, Luoyang Orthopedic-Traumatological Hospital of Henan Province), Lu Huang (0000-0002-1211-5441, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine), Jiahao Duan (0000-0002-1537-3323, Hunan University of Traditional Chinese Medicine), Gaoyan Kuang (0000-0003-2256-079X, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine), Min Lu (0000-0003-3397-3637, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine), Xuyi Tan (Hunan University of Traditional Chinese Medicine, autor correspondente)
Ano2022
Volume294
Páginas115363
Data de publicação2022-08-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Ethnopharmacology (JOURNAL)
Identificadores do periódicoISSN: 0378-8741 • E-ISSN: 1872-7573
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2022.115363
PMID35551975
OpenAlexW4229445536
IdiomaEN
Citações recebidas2
Referências citadas15

JDJM can regulate the synovial Wnt/β-catenin signaling pathway in KOA models, reduce the mRNA transcription and protein expression levels of Wnt3a, β-catenin, Cyclin D1, MMP-7, and COX-2 in the synovium, thus inhibiting synovial inflammation and protecting articular cartilage, which could be the key mechanism of action in treating this disease

Biology · Cancer · Catenin · Cell cycle · Cyclin D1 · In vitro · In vivo · Inflammation · Matrix metalloproteinase · Osteoarthritis · Pathogenesis · Pathology · Signal transduction · Wnt signaling pathway · Cancer-related gene regulation · Chemistry · Medicine · Osteoarthritis Treatment and Mechanisms · Wnt/β-catenin signaling in development and cancer · Biochemistry · Cancer Research · Immunology · Internal Medicine · Pharmacology