Optimization of self‐ or parent‐reported psychiatric phenotypes in longitudinal studies

Dados Bibliográficos

ID21344476
AutoresFranjo Ivankovic (0000-0002-6776-8626, Analytic and Translational Genetics Unit Massachusetts General Hospital Boston MA USA, autor correspondente), Sharon Johnson (0000-0003-2304-6581, Department of Psychiatry, Center for OCD, Anxiety and Related Disorders, McKnight Brain Institute University of Florida College of Medicine Gainesville FL USA), James Shen (Department of Psychiatry, Center for OCD, Anxiety and Related Disorders, McKnight Brain Institute University of Florida College of Medicine Gainesville FL USA), Jeremiah M Scharf (0000-0002-4742-5896, Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA USA), Carol A Mathews (0000-0003-2208-7058, Genetics & Genomics Graduate Program University of Florida Genetics Institute Gainesville FL USA)
Ano2025
Volume66
Fascículo2
Páginas253-265
Data de publicação2025-02-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Child Psychology and Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 0021-9630 • E-ISSN: 1469-7610
EditoraWiley (PUBLISHER • GB)
DOI10.1111/jcpp.14054
PMID39246252
OpenAlexW4402377506
IdiomaEN
Citações recebidas1
Referências citadas45

BACKGROUND: The Adolescent Brain Cognitive Development (ABCD) study is a longitudinal study of US adolescents with a wide breadth of psychiatric, neuroimaging and genetic data that can be leveraged to better understand psychiatric diseases. The reliability and validity of the psychiatric data collected have not yet been examined. This study aims to explore and optimize the reliability/validity of psychiatric diagnostic constructs in the ABCD study. METHODS: Parent-and-child-reported psychiatric data for 11,876 children (aged 9.5 ± 0.5 at first assessment) were examined over 4 years to derive specific constructs for psychiatric diagnoses using longitudinal information. Rates of psychiatric disorders were calculated and compared to those reported in the epidemiological literature. RESULTS: The rates of self-reported psychiatric disorders at any single time point (broad diagnostic construct) were higher than indicated by epidemiological studies. Narrow diagnostic constructs, which required the endorsement of psychiatric disorders at a majority of longitudinal assessments, demonstrated a better rate approximation of literature-reported prevalences for most disorders (e.g. the prevalence of broad obsessive-compulsive disorder (OCD) was 13.3% compared to narrow OCD at 2.6% and a literature-reported prevalence of 2.3%). Analysis of comorbidity, using OCD as a representative example, also showed a better approximation of literature-reported comorbidity rates using the narrow construct, with some exceptions. CONCLUSIONS: Self- or parent-report-based assessments tend to overestimate prevalences of psychiatric disorders in the ABCD Study, particularly when longitudinal data are summed to create lifetime prevalences. Such assessments should be accompanied by more in-depth assessments or clinician-administered structured interviews if using data where accurate disorder classifications are paramount

Cognition · Comorbidity · Epidemiology of child psychiatric disorders · Longitudinal study · Mental health · Psychiatric comorbidity · Psychiatric diagnosis · Psychiatric epidemiology · Psychiatry · Attention Deficit Hyperactivity Disorder · Child and Adolescent Psychosocial and Emotional Development · Clinical Psychology · Epidemiology · Medicine · Obsessive-Compulsive Spectrum Disorders · Psychology