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Incentive‐sensitization and addiction

Dados Bibliográficos

ID23314720
AutoresTodd E Robinson (0000-0001-7861-3737, University of Michigan), Terry E Robinson, Kent C Berridge (0000-0002-6031-2626, University of Michigan)
Ano2001
Volume96
Fascículo1
Páginas103-114
Data de publicação2001-01-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAddiction (JOURNAL)
Identificadores do periódicoISSN: 0965-2140 • E-ISSN: 1360-0443
EditoraWiley (PUBLISHER • GB)
DOI10.1046/j.1360-0443.2001.9611038.x
PMID11177523
OpenAlexW2146938761
IdiomaEN
Citações recebidas84
Referências citadas3

The question of addiction concerns the process by which drug‐taking behavior, in certain individuals, evolves into compulsive patterns of drug‐seeking and drug‐taking behavior that take place at the expense of most other activities, and the inability to cease drug‐taking, that is, the problem of relapse. In this paper we summarize one view of this process, the "incentive‐sensitization" view, which we first proposed in 1993. Four major tenets of the incentive‐sensitization view are discussed. These are: (1) potentially addictive drugs share the ability to alter brain organization; (2) the brain systems that are altered include those normally involved in the process of incentive motivation and reward; (3) the critical neuroadaptations for addiction render these brain reward systems hypersensitive ("sensitized") to drugs and drug‐associated stimuli; and (4) the brain systems that are sensitized do not mediate the pleasurable or euphoric effects of drugs (drug "liking"), but instead they mediate a subcomponent of reward we have termed incentive salience (drug "wanting").

Addiction · Behavioral sensitization · Brain stimulation reward · Cognitive psychology · Dopamine · Drug · Incentive · Incentive salience · Microeconomics · Nucleus accumbens · Psychiatry · Reward system · Salience (neuroscience) · Sensitization · Neural and Behavioral Psychology Studies · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychedelics and Drug Studies · Psychology

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