The diagnosis of dementia due to Alzheimer's disease

Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Dados Bibliográficos

ID23345129
AutoresGuy M Mckhann (0000-0002-9695-3564, Allen Institute for Brain Science, autor correspondente), David S Knopman (0000-0002-6544-066X, Mayo Clinic in Arizona), Howard Chertkow (0000-0003-3749-8132, McGill University), Bradley T Hyman (0000-0002-7959-9401, Harvard University), Clifford R Jack (0000-0001-7916-622X, Mayo Clinic in Arizona), Claudia H Kawas (0000-0001-9577-230X, University of California, Irvine), William E Klunk (0000-0001-5512-0251, University of Pittsburgh), Walter J Koroshetz (0000-0001-7292-7831, National Institute of Neurological Disorders and Stroke), Jennifer J Manly (0000-0002-9481-7497, Columbia University Irving Medical Center), Richard Mayeux (0000-0001-6519-9696, Columbia University Irving Medical Center), Richard C Mohs (0000-0002-3765-6287, Eli Lilly (United States)), John C Morris (0000-0001-9820-5618, Washington University in St. Louis), Martin N Rossor (0000-0001-8215-3120, UK Dementia Research Institute), Philip Scheltens (0000-0002-1046-6408, Amsterdam UMC Location Vrije Universiteit Amsterdam), Marco Chivalán Carrillo (0000-0003-3057-2387, Alzheimer's Association), Maria C Carrillo (Alzheimer's Association Chicago IL USA), Bill Thies (Alzheimer's Association), Sandra Weintraub (Department of Psychiatry Northwestern Feinberg School of Medicine Chicago IL USA), Sandra Weıntraub (0000-0003-2605-5205, Northwestern University), Creighton H Phelps (National Institute on Aging)
Ano2011
Volume7
Fascículo3
Páginas263-269
Data de publicação2011-05-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAlzheimer's & Dementia (JOURNAL)
Identificadores do periódicoISSN: 1552-5260 • E-ISSN: 1552-5279
EditoraWiley (PUBLISHER • GB)
DOI10.1016/j.jalz.2011.03.005
PMID21514250
PMCIDPMC3312024
OpenAlexW2115017507
IdiomaEN
Citações recebidas224
Referências citadas27

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexible enough to be used by both general healthcare providers without access to neuropsychological testing, advanced imaging, and cerebrospinal fluid measures, and specialized investigators involved in research or in clinical trial studies who would have these tools available. We present criteria for all‐cause dementia and for AD dementia. We retained the general framework of probable AD dementia from the 1984 criteria. On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. Biomarker evidence was also integrated into the diagnostic formulations for probable and possible AD dementia for use in research settings. The core clinical criteria for AD dementia will continue to be the cornerstone of the diagnosis in clinical practice, but biomarker evidence is expected to enhance the pathophysiological specificity of the diagnosis of AD dementia. Much work lies ahead for validating the biomarker diagnosis of AD dementia.

Alzheimer's disease · Association (psychology) · Dementia · Disease · Pathology · Psychiatry · Psychotherapist · Alzheimer's disease research and treatments · Dementia and Cognitive Impairment Research · Frailty in Older Adults · Medicine · Psychology · Gerontology