Long-lasting analgesic effect of the psychedelic drug changa

A case report

Dados Bibliográficos

ID4686302
AutoresGenís Ona (0000-0003-2741-2876, Universitat Rovira i Virgili, autor correspondente), Sebastián Peña Troncoso (0000-0002-5438-0868, Universitat Rovira i Virgili), Sebastián Troncoso
Ano2019
Volume3
Fascículo1
Páginas7-13
Data de publicação2019-03-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Psychedelic Studies (JOURNAL)
Identificadores do periódicoISSN: 2559-9283 • E-ISSN: 2559-9283
EditoraAkademiai Kiado Zrt (PUBLISHER)
DOI10.1556/2054.2019.001
OpenAlexW2914689341
IdiomaEN
Citações recebidas1
Referências citadas66

Background and aims: Pain is the most prevalent symptom of a health condition, and it is inappropriately treated in many cases. Here, we present a case report in which we observe a long-lasting analgesic effect produced by changa, a psychedelic drug that contains the psychoactive N,N-dimethyltryptamine and ground seeds of Peganum harmala, which are rich in -carbolines. Methods: We describe the case and offer a brief review of supportive findings. Results: A long-lasting analgesic effect after the use of changa was reported. Possible analgesic mechanisms are discussed. We suggest that both pharmacological and non-pharmacological factors could be involved. Conclusion: These findings offer preliminary evidence of the analgesic effect of changa, but due to its complex pharmacological actions, involving many neurotransmitter systems, further research is needed in order to establish the specific mechanisms at work

Analgesic · Dopamine · Drug · Neurotransmitter systems · Cannabis and Cannabinoid Research · Chemical synthesis and alkaloids · Medicine · Psychedelics and Drug Studies · Internal Medicine · Pharmacology