Genetic Determination of Osteoporosis
Lessons Learned from a Large Genome-Wide Linkage Study
Dados Bibliográficos
| ID | 8960669 |
|---|---|
| Autores | Dong-Hai Xiong (Xi'an Jiaotong University, autor correspondente), Jin-Tang Wang (autor correspondente), Wei Wang (0000-0001-5806-2368, Xi'an Jiaotong University, autor correspondente), Yan-Fang Guo (0009-0008-7689-0464, autor correspondente), Peng Xiao (0000-0003-0075-581X, Xi'an Jiaotong University, autor correspondente), Hui Shen (0000-0001-9767-4084, autor correspondente), Hui Jiang (0000-0001-8393-8368, Xi'an Jiaotong University, autor correspondente), Yuan Chen (0000-0002-7069-1631, Xi'an Jiaotong University, autor correspondente), Hongyi Deng (0009-0000-8216-433X, autor correspondente), Betty M Drees (autor correspondente), Robert R Recker (0000-0002-8774-1404, Xi'an Jiaotong University, autor correspondente), Hong‐wen Deng (0000-0002-0387-8818, autor correspondente) |
| Ano | 2007 |
| Volume | 79 |
| Fascículo | 6 |
| Páginas | 593-608 |
| Data de publicação | 2007-12-01 |
| Peer Reviewed | Sim |
| Open Access | Não |
| Tipo | ARTICLE |
| Periódico | Human Biology (JOURNAL) |
| Identificadores do periódico | ISSN: 0018-7143 • E-ISSN: 1534-6617 |
| Editora | Human Biology (The International Journal of Population Biology and Genetics) (PUBLISHER) |
| DOI | 10.1353/hub.2008.0018 |
| PMID | 18494371 |
| OpenAlex | W1879312632 |
| Idioma | EN |
| Referências citadas | 1 |
Osteoporosis is a common disease with strong genetic control. We performed an autosomal linkage scan in a large pedigree-based sample of 4,498 subjects for a composite osteoporosis phenotype that combines osteoporotic fracture (OF) and low bone mineral density (BMD). All of the subjects were U.S. Caucasians recruited in the Omaha area of Nebraska. Sex-specific linkage analyses and autosomal imprinting analyses were also conducted. For conventional linkage analyses in the total sample, we identified suggestive linkage on chromosomes 14q32 (LOD = 2.61), 7p14 (LOD = 2.42), and 11q25 (LOD = 2.09). In female subjects a significant linkage signal was detected on chromosome 14q22 (LOD = 3.53) and another two peaks were detected on chromosomes 7p14 (LOD = 3.07) and 9p21 (LOD = 2.29). Suggestive evidence of imprinted loci was found with paternally derived alleles on chromosomes 1q42 (LOD = 2.12) and 9q34 (LOD = 1.88). Some evidence of linkage to maternally derived alleles was found on chromosome 7q22 (LOD = 1.67). Our study provides new clues to osteoporosis genetic research and for the first time suggests that genomic imprinting effects may play a role in the etiology of osteoporosis
Allele · Biology · Chromosome · Gene · Genetic linkage · Genomic Imprinting · Imprinting (psychology · Linkage (software · Osteoporosis · Endocrinology · Epigenetics and DNA Methylation · Genetic Associations and Epidemiology · Genetic Syndromes and Imprinting · Genetics
| Velocidade de citação | historical |
|---|---|
| Altamente citado | Não |