Influence of the Specific Immune Response on Some Consistent Murine Behaviors

The author's goal was to discover if the generation and maintenance of the specific immune response resulted in alterations of reliable behaviors (i.e., behaviors correlated over time). The behaviors (ambulation, rearing, and interaction with a conspecific) of CD1 male mice were measured in a small open field, and several days later, the mice were immunized with antigens (either splenocytes from C57BL/6 mice or a mixture of sheep erythrocytes and goat serum). The same behaviors were recorded again some hours, or some days, after immunization. Immunizations and behavioral measurements were repeated at various intervals. Blood levels of antibodies to the antigens were measured 6 days after immunization. The recorded behaviors were consistent (according to Kendall coefficient of concordance). The mice mounted antibody responses to the antigens, yet no behavioral changes were apparent during the response. On the contrary, a single injection of E. coli lipopolysaccharide decreased ambulation and rearing. It is proposed that in healthy mice kept in normal conditions, the specific immune response may be unrelated to reliable behavioral changes

Biology · Immune system · Circadian rhythm and melatonin · Immunology · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders

• Reliability of Various Measures Obtained in Open-Field Test

  Open Access•Montserrat Gomà‐i‐Freixanet, Montserrat Goma et al.•Psychological Reports•1978

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