Establishing Genotype/Phenotype Relationships
Gene Targeting as an Experimental Approach
Bibliographic Data
| ID | 10703121 |
|---|---|
| Authors | Sylvia Culp (Western Michigan University, corresponding author) |
| Year | 1997 |
| Volume | 64 |
| Issue | S4 |
| Pages | S268-S278 |
| Publication date | 1997-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Philosophy of Science (JOURNAL) |
| Journal identifiers | ISSN: 0031-8248 • E-ISSN: 1539-767X |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1086/392606 |
| OpenAlex | W2056141398 |
| Language | EN |
| Citations received | 1 |
| References cited | 18 |
In this paper, I examine an experimental technique, gene targeting, used for establishing genotype/phenotype relationships. Through analyzing a case study, I identify many pitfalls that may lead to false conclusions about these relationships. I argue that some of these pitfalls may seriously affect gene targeting's usefulness for associating phenotypes with genes cataloged by the Human Genome Project. This case also shows the use of gene targeted mice as model systems for studying genotype/phenotype relationships in humans. Moreover, I argue that it reveals the weakness of one attempt to draw conclusions about the biological determination of sexual and aggressive behaviors in humans
Affect (linguistics) · Biology · Computational biology · Gene · Genotype · Genotype-phenotype distinction · Phenotype · Genetics · Neuroendocrine regulation and behavior · Psychology · Receptor Mechanisms and Signaling
| Citations per year | 0.03 |
|---|---|
| Citation span | 1997 - 1997 (1) |
| Highly cited | No |