Neonatal tetanus in Peru
Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test
Bibliographic Data
| ID | 11021948 |
|---|---|
| Authors | Louis Vernacchio (0000-0002-2012-5404, Johns Hopkins University), Guillermo Madico (Johns Hopkins University), Manuela Verastegui (0000-0002-7500-1353, Johns Hopkins University), F Díaz (0000-0003-4117-8203, Johns Hopkins University), Timothy S Collins (Johns Hopkins University), Robert H Gilman (0000-0002-9037-0712, Johns Hopkins University) |
| Year | 1993 |
| Volume | 83 |
| Issue | 12 |
| Pages | 1754-1756 |
| Publication date | 1993-12-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | American Journal of Public Health (JOURNAL) |
| Journal identifiers | ISSN: 0090-0036 • E-ISSN: 1541-0048 |
| Publisher | American Public Health Association (PUBLISHER • US) |
| DOI | 10.2105/ajph.83.12.1754 |
| PMID | 8259811 |
| OpenAlex | W2147510471 |
| Language | EN |
| References cited | 8 |
We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (> or = 0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world
Antibody · Antitoxin · Biology · Immune system · Immunity · Neonatal tetanus · Pregnancy · Tetanus · Titer · Toxin · Toxoid · Vaccination · Botulinum Toxin and Related Neurological Disorders · Diphtheria, Corynebacterium, and Tetanus · Immunology · Intramuscular injections and effects · Medicine · Microbiology
| Highly cited | No |
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