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Neural tube defects in Jamaica following Hurricane Gilbert

Bibliographic Data

ID11026440
AuthorsE M Duff, Vanessa El Khoury (Laboratoire d'Informatique en Images et Systèmes d'Information, corresponding author), E S Cooper
Year1994
Volume84
Issue3
Pages473-476
Publication date1994-03-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.84.3.473
OpenAlexW8129070
LanguageEN
Citations received12
References cited14

An increased incidence of obvious live-birth neural tube defects (i.e., spina bifida cystica and encephalocele) occurred in Jamaica 11 to 18 months after Hurricane Gilbert. The conceptions of the affected babies coincided with a rise in megaloblastic change in sickle cell patients, suggesting a wide-spread drop in dietary folate intake. A detailed history was taken from each of the 17 affected mothers (case subjects) and 51 unaffected mothers (matched control subjects). The case subjects reported a significantly lower mean intake of dietary folate in the periconceptional period (154 micrograms/day) than did the control subjects (254 micrograms/day). The temporary increase in neural tube defects was associated with a diet comparatively low in folate in the periconceptional period, suggesting the dietary level of folate that fails to protect against neural tube defects under natural conditions

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Unique citing works12
Citations per year0,38
Citation span1994 - 2021 (28)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 12

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