Lead-induced anemia
Dose-response relationships and evidence for a threshold
Bibliographic Data
| ID | 11029319 |
|---|---|
| Authors | Joel Schwartz (0000-0001-6168-378X, Environmental Protection Agency), Philip J Landrigan (0000-0002-0150-6914, Icahn School of Medicine at Mount Sinai), Edward L Baker, Walter A Orenstein (0000-0003-3932-8209, Icahn School of Medicine at Mount Sinai), Ian H von Lindern (Icahn School of Medicine at Mount Sinai) |
| Year | 1990 |
| Volume | 80 |
| Issue | 2 |
| Pages | 165-168 |
| Publication date | 1990-02-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | American Journal of Public Health (JOURNAL) |
| Journal identifiers | ISSN: 0090-0036 • E-ISSN: 1541-0048 |
| Publisher | American Public Health Association (PUBLISHER • US) |
| DOI | 10.2105/ajph.80.2.165 |
| PMID | 2297059 |
| OpenAlex | W2144507972 |
| Language | EN |
| Citations received | 4 |
| References cited | 12 |
We conducted a cross-sectional epidemiologic study to assess the association between blood lead level and hematocrit in 579 one to five year-old children living near a primary lead smelter in 1974. Blood lead levels ranged from 0.53 to 7.91 mumol/L (11 to 164 micrograms/dl). To predict hematocrit as a function of blood lead level and age, we derived non-linear regression models and fit percentile curves. We used logistic regression to predict the probability of hematocrit values less than 35 per cent. We found a strong non-linear, dose-response relationship between blood lead level and hematocrit. This relationship was influenced by age, but (in this age group) not by sex; the effect was strongest in youngest children. In one year-olds, the age group most severely affected, the risk of an hematocrit value below 35 percent was 2 percent above background at blood lead levels between 0.97 and 1.88 mumol/L (20 and 39 micrograms/dl), 18 percent above background at lead levels of 1.93 to 2.85 mumol/L (40 to 59 micrograms/dl), and 40 percent above background at lead levels of 2.9 mumol/L (60 micrograms/dl) and greater; background was defined as a blood lead level below 1.88 mumol/L (20 micrograms/dl). This effect appeared independent of iron deficiency. These findings suggest that blood lead levels close to the currently recommended limit value of 1.21 mumol/L (25 micrograms/dl) are associated with dose-related depression of hematocrit in young children
Anemia · Biology · Hematocrit · Lead (geology) · Lead exposure · Lead poisoning · Lead smelting · Linear regression · Logistic regression · Percentile · Chemistry · Heavy Metal Exposure and Toxicity · Internal Medicine · Iron Metabolism and Disorders · Medicine · Physiology · Trace Elements in Health
Lead (Pb) and cadmium (Cd) blood levels and potential hematological health risk among inhabitants of the claimed hazardous region around Qaroun Lake in Egypt
Knowledge, attitude, and practices related to lead pollution among adolescents and caregivers of young children living near Used Lead Acid Battery (Ulab) recycling sites in Bangladesh
Blood lead levels in children from Sardinian villages at high risk of environmental crisis
Mines
| Unique citing works | 4 |
|---|---|
| Citations per year | 0,17 |
| Citation span | 2002 - 2024 (23) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 4 |