Increasing Prescription Opioid and Heroin Overdose Mortality in the United States, 1999–2014

An Age–Period–Cohort Analysis

Bibliographic Data

ID11029973
AuthorsXiwen Huang (0000-0003-2174-1767, All of the authors are with the Department of Epidemiology, Mailman School of Public Health, and the Center for Injury Epidemiology and Prevention, Columbia University, New York, NY. Guohua Li is also with the Department of Anesthesiology, College of Physicians and Surgeons, Columbia University.), Katherine M Keyes (0000-0002-5624-021X, All of the authors are with the Department of Epidemiology, Mailman School of Public Health, and the Center for Injury Epidemiology and Prevention, Columbia University, New York, NY. Guohua Li is also with the Department of Anesthesiology, College of Physicians and Surgeons, Columbia University.), Guohua Li (0000-0003-4732-2448, All of the authors are with the Department of Epidemiology, Mailman School of Public Health, and the Center for Injury Epidemiology and Prevention, Columbia University, New York, NY. Guohua Li is also with the Department of Anesthesiology, College of Physicians and Surgeons, Columbia University.)
Year2018
Volume108
Issue1
Pages131-136
Publication date2018-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2017.304142
PMID29161066
OpenAlexW2769257736
LanguageEN
Citations received11
References cited23

Objectives. To assess cohort effects in prescription opioid and heroin overdose mortality in the United States. Methods. Using the National Center for Health Statistics’ multiple-cause-of-death file for 1999 to 2014, we performed an age–period–cohort analysis of drug overdose mortality in the United States. Results. Compared with those born in 1977 and 1978, individuals born between 1947 and 1964 experienced excess risks of prescription opioid overdose death (e.g., for the 1955–1956 birth cohort, rate ratio [RR] = 1.27; 95% confidence interval [CI] = 1.09, 1.48) and of heroin overdose death (e.g., for the 1953–1954 birth cohort, RR = 1.32; 95% CI = 1.11, 1.57). Those born between 1979 and 1992 also experienced an increased risk of heroin overdose death (e.g., for the 1989–1990 birth cohort, RR = 1.23; 95% CI = 1.01, 1.50). The cohort effects were consistent between sexes. Conclusions. Individuals born between 1947 and 1964 and between 1979 and 1992 are particularly afflicted by the opioid epidemic. Intervention programs are needed to reduce the excess overdose mortality in these specific demographic groups

(+)-Naloxone · Cohort · Cohort study · Confidence interval · Drug · Drug overdose · Heroin · Medical prescription · Mortality rate · Opioid · Opioid overdose · Poison control · Psychiatry · Demography · Emergency Medicine · Internal Medicine · Medicine · Opioid Use Disorder Treatment · Pharmacology · Prenatal Substance Exposure Effects · Suicide and Self-Harm Studies

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