Trends in Ketamine Use, Exposures, and Seizures in the United States up to 2019

Bibliographic Data

ID11034191
AuthorsJoseph J Palamar (0000-0002-8565-9415, Joseph J. Palamar is with the Department of Population Health, New York University Grossman School of Medicine, New York, NY. Caroline Rutherford and Katherine M. Keyes are with the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.), Caroline Rutherford (0000-0001-8611-0523, Joseph J. Palamar is with the Department of Population Health, New York University Grossman School of Medicine, New York, NY. Caroline Rutherford and Katherine M. Keyes are with the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.), Katherine M Keyes (0000-0002-5624-021X, Joseph J. Palamar is with the Department of Population Health, New York University Grossman School of Medicine, New York, NY. Caroline Rutherford and Katherine M. Keyes are with the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.)
Year2021
Volume111
Issue11
Pages2046-2049
Publication date2021-11-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2021.306486
PMID34618543
OpenAlexW3203575693
LanguageEN
Citations received4
References cited7

Objectives. To determine whether there have been shifts in nonmedical ketamine use, poisonings (“exposures”), and seizures. Methods. We used generalized additive models to detect trends in past-year use (2006–2019), exposures (1991–2019), and seizures (2000–2019) involving ketamine in the United States. Results. There was a quarterly increase in self-reported past-year nonmedical ketamine use in 2006 to 2014 (Β = 0.21; P = .030) and an increase in 2015 to 2019 (Β = 0.29; P = .036), reaching a peak of 0.9% in late 2019. The rate of exposures increased from 1991 through 2019 (Β = 0.87; P = .006), and there was an increase to 1.1 exposures per 1 000 000 population in 2014, with rates remaining stable through 2019. The rate of ketamine seizures increased from 2000 through 2019 (Β = 2.27; P Conclusions. Indicators suggest that ketamine use and availability has increased, including before increased medical indications, but nonmedical use is still currently uncommon despite increased acceptance and media coverage. (Am J Public Health. 2021;111(11):2046–2049. https://doi.org/10.2105/AJPH.2021.306486 )

Environmental health · Ketamine · Population · Psychiatry · Public health · Alcoholism and Thiamine Deficiency · Medicine · Treatment of Major Depression · Tryptophan and brain disorders · Pediatrics

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