Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women

Bibliographic Data

ID11040244
AuthorsAaron R Folsom (0000-0003-2635-2699, University of Minnesota), Pamela J Mink (0000-0003-2512-3253, University of Minnesota, Duluth), Thomas A Sellers (0000-0002-7832-0405, University of Minnesota, Duluth), C P Hong (University of Minnesota, Duluth), Wei Zheng (0000-0002-3339-5606, University of Minnesota, Duluth), John D Potter (0000-0001-5439-1500, University of Minnesota, Duluth)
Year1995
Volume85
Issue8_Pt_1
Pages1128-1132
Publication date1995-08-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.85.8_pt_1.1128
PMID7625511
OpenAlexW1974906470
LanguageEN
Citations received2
References cited29

We assessed the association of hormonal replacement therapy with mortality and incidence of multiple diseases in over 40,000 postmenopausal women followed for 6 years as part of the Iowa Women's Health Study. Compared with women who never used hormone replacement therapy, current users had multivariate adjusted relative risks (RR) as follows: total mortality (RR = 0.78; 95% confidence interval [CI] = 0.65, 0.94), coronary heart disease mortality (RR = 0.74; 95% CI = 0.48, 1.12), endometrial cancer incidence (RR = 4.3; 95% CI = 2.7, 6.9), breast cancer incidence (RR = 1.23; 95% CI = 0.99, 1.55), colon cancer incidence (RR = 0.72; 95% CI = 0.46, 1.12), and hip fracture incidence (RR = 0.53; 95% CI = 0.31, 0.91)

Breast cancer · Cancer · Confidence interval · Endometrial cancer · Gynecology · Hormone replacement therapy (female-to-male) · Incidence (geometry) · Obstetrics · Prospective cohort study · Relative risk · Testosterone (patch) · Cancer Risks and Factors · Estrogen and related hormone effects · Internal Medicine · Medicine · Menopause: Health Impacts and Treatments

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