Ventilatory function, height, and mortality among lifelong non-smokers
Bibliographic Data
| ID | 11178180 |
|---|---|
| Authors | D P Strachan (0000-0001-7854-1366, London School of Hygiene & Tropical Medicine, corresponding author) |
| Year | 1992 |
| Volume | 46 |
| Issue | 1 |
| Pages | 66-70 |
| Publication date | 1992-02-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.46.1.66 |
| PMID | 1573363 |
| OpenAlex | W1996024740 |
| Language | EN |
| Citations received | 6 |
| References cited | 15 |
STUDY OBJECTIVE--The aims were to determine the relationship between spirometric indices and mortality among lifelong non-smokers, and to investigate whether the association of short stature with increased risk of death is explained by reduced levels of ventilatory function in shorter men. DESIGN--The study was a nested (within cohort) case-control analysis of an 18 year prospective study of mortality. SUBJECTS--Participants were 3452 male civil servants aged 40-64 years at entry who denied ever having smoked tobacco. MEASUREMENTS AND MAIN RESULTS--408 men who died were matched to 2874 controls of the same age and height. Reduced one second forced expiratory volume (FEV1) was associated with mortality from non-respiratory causes (rate ratio per litre decrease = 1.44, 95% confidence interval 1.196-1.73). The ratio of FEV1 to forced vital capacity was a weak predictor of mortality. Among 397 case-control sets matched for age and FEV1, mortality was unrelated to height. Comparing mortality differentials across age adjusted tertiles of each risk factor, height adjusted FEV1 was a stronger predictor of death than height, body mass index, or plasma cholesterol. FEV1 adjusted for age but not for height was almost as strong a predictor as systolic blood pressure. CONCLUSIONS--The determinants of ventilatory function in lifelong non-smokers may include causes of premature death. FEV1 may be a more sensitive indicator than height of early life influences upon mortality
Body mass index · Cardiology · Cohort · Cohort study · Confidence interval · Lung · Lung function · Mortality rate · Prospective cohort study · Risk factor · Vital capacity · Asthma and respiratory diseases · Chronic Obstructive Pulmonary Disease (COPD) Research · Demography · Internal Medicine · Medicine · Respiratory Support and Mechanisms
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| Citations per year | 0.18 |
|---|---|
| Citation span | 1992 - 2012 (21) |
| Highly cited | No |