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Alcohol intake and cardiovascular disease and mortality

The role of pre-existing disease

Bibliographic Data

ID11178809
AuthorsI H M Friesema, Ingrid Friesema (0000-0001-9943-0518, Maastricht University, corresponding author), P J Zwietering (Maastricht University), M Y Veenstra, M Veenstra (0000-0002-2786-3776, IVO Addiction Research Institute), J André Knottnerus (0000-0001-8159-4696, Maastricht University), H F L Garretsen (0000-0002-4759-2651, Tilburg University), Paul Lemmens (0000-0002-7847-4586, Maastricht University), P H H M Lemmens
Year2007
Volume61
Issue5
Pages441-446
Publication date2007-05-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueJournal of Epidemiology and Community Health (JOURNAL)
Journal identifiersISSN: 0143-005X • E-ISSN: 1470-2738
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/jech.2006.050419
PMID17435212
PMCIDPMC2465695
OpenAlexW2111652765
LanguageEN
Citations received3
References cited21

Objectives: Pre-existing conditions have been postulated as possible causes of the J-shaped relationship between alcohol intake and cardiovascular disease. Two research questions have been addressed in this paper. First, whether never drinkers and former drinkers differ from moderate drinkers in terms of health, and if so, which health problems contribute to this difference. Second, whether the U-shaped relationship between current alcohol intake and cardiovascular disease or all-cause mortality could in part be explained by difference in pre-existing disease burden. Design, setting and participants: A prospective case-cohort, the Lifestyle and Health Study, consisting of 16 210 men and women aged between 45 and 70 years. Alcohol intake and risk factors were assessed at baseline with a self-administered questionnaire. Medical information was obtained from general practitioners. Cardiovascular events and mortality were followed for a period of 5 years (1996–2001). Main results: Never drinkers and former drinkers were less healthy than moderate drinkers. They rated their health more often as poor, and often had more diseases, such as cardiovascular disease, diabetes, and also alcohol-related diseases. The difference in disease burden did not change the observed relationship between alcohol intake and cardiovascular events, and only partially changed the U-shaped relationship between alcohol intake and all-cause mortality. Conclusions: The found difference in health between never drinkers and former drinkers compared with moderate drinkers appeared to be only a partial explanation of the observed relationships between alcohol intake and cardiovascular disease, and between alcohol intake and all-cause mortality

Alcohol · Alcohol intake · Cardiovascular health · Cohort · Cohort study · Diabetes mellitus · Disease · Environmental health · Prospective cohort study · Alcohol Consumption and Health Effects · Alcoholism and Thiamine Deficiency · Endocrinology · Internal Medicine · Medicine · Substance Abuse Treatment and Outcomes · Gerontology

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Unique citing works3
Citations per year0,19
Citation span2010 - 2020 (11)
Citation velocityhistorical
Highly citedNo
Citation typesNeutral: 3

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