The Age at Menarche
Bibliographic Data
| ID | 11180337 |
|---|---|
| Authors | Perry Brown (University of Sheffield, corresponding author), P E Brown |
| Year | 1966 |
| Volume | 20 |
| Issue | 1 |
| Pages | 9-14 |
| Publication date | 1966-01-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.20.1.9 |
| OpenAlex | W2020872918 |
| Language | EN |
| Citations received | 19 |
| References cited | 3 |
Serotonin (5-HT) modulates neural responses to socioaffective cues and can bias approach or avoidance behavioral decisions, yet the cellular mechanisms underlying its contribution to the regulation of social experiences remain poorly understood. We hypothesized that GABAergic neurons in the dorsal raphe nucleus (DRN) may participate in socioaffective regulation by controlling serotonergic tone during social interaction. We tested this hypothesis using whole-cell recording techniques in genetically identified DRN GABA and 5-HT neurons in mice exposed to social defeat, a model that induces long-lasting avoidance behaviors in a subset of mice responsive to serotonergic antidepressants. Our results revealed that social defeat engaged DRN GABA neurons and drove GABAergic sensitization that strengthened inhibition of 5-HT neurons in mice that were susceptible, but not resilient to social defeat. Furthermore, optogenetic silencing of DRN GABA neurons disinhibited neighboring 5-HT neurons and prevented the acquisition of social avoidance in mice exposed to a social threat, but did not affect a previously acquired avoidance phenotype. We provide the first characterization of GABA neurons in the DRN that monosynaptically inhibit 5-HT neurons and reveal their key role in neuroplastic processes underlying the development of social avoidance
Developmental psychology · Dorsal raphe nucleus · GABAergic · Inhibitory postsynaptic potential · Neuroplasticity · Optogenetics · Raphe nuclei · Serotonergic · Serotonin · Social behavior · Social defeat · Internal Medicine · Medicine · Neuroendocrine regulation and behavior · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Psychology · Receptor Mechanisms and Signaling
Body size and fatness in young adults in relation to age at menarche
A comparative analysis of estimation of age at menarche by various methods in women participating in the Krakow Longitudinal Growth Study, Poland
Family composition and menarcheal age
Age at Menarche in Three Caste Populations of Andhra Pradesh
Variation in the Age at Menarche of the Assamese and Bengali Girls of Guwahati, Assam
L'âge des premières règles en France, 1750-1950
The age of menarche in Nigerian urban school girls
Association of maternal menarcheal age with anthropometric dimensions and blood pressure in children from Greater Bilbao
The effect of homozygous sickle cell disease on the age at menarche in Nigerian schoolgirls
Age at menarche in Coimbra (Portugal) school girls
Light, puberty, and aggression
Clandestine marriage in early modern London
"A critical notice of Brown on "the age at menarche
Use of Social Indices in Psychiatric Epidemiology
Possible Stabilization of the Age at Menarche in Northwestern United States
Thorarche—a seasonal influence but no secular trend
Contemporary and Historical Evidence to Suggest that Women’s Preference for Age at Birth of First Child Remains Consistent Across Time
A forty‐five year investigation for secular changes in physical maturation
Social determinants of the onset of puberty in rodents∗
| Unique citing works | 19 |
|---|---|
| Citations per year | 0.32 |
| Citation span | 1966 - 2015 (50) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |