Effects of 3-week total meal replacement vs. typical food-based diet on human brain functional magnetic resonance imaging food-cue reactivity and functional connectivity in people with obesity
Bibliographic Data
| ID | 11355705 |
|---|---|
| Authors | Chanaka N Kahathuduwa (0000-0003-2049-4901, University of Peradeniya), Tyler Davis (Texas Tech University), Michael O'Boyle, Michael W O’boyle (0000-0001-8604-7421, Texas Tech University), Lori A Boyd (0000-0001-9284-5091, Texas Tech University), Shao-Hua Chin (Texas Tech University), Dmitrii Paniukov (Texas Tech University), Martin Binks (0000-0001-8759-4048, Texas Tech University, corresponding author) |
| Year | 2018 |
| Volume | 120 |
| Pages | 431-441 |
| Publication date | 2018-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Appetite (JOURNAL) |
| Journal identifiers | ISSN: 0195-6663 • E-ISSN: 1095-8304 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.appet.2017.09.025 |
| PMID | 28958900 |
| OpenAlex | W2760506034 |
| Language | EN |
| Citations received | 1 |
| References cited | 37 |
OBJECTIVES: Calorie restriction via total meal replacement (TMR) results in greater reduction of food cravings compared to reduced-calorie typical diet (TD). Direct evidence of the impact of these interventions on human brain fMRI food-cue reactivity (fMRI-FCR) and functional connectivity is absent. We examined the effects of a 3-week 1120 kcal/d TMR intervention as compared to an iso-caloric TD intervention using an fMRI-FCR paradigm. METHODS: ) participated in a randomized two-group repeated measures dietary intervention study consisting of 1120 kcal/d from either 1) TMR (shakes), 2) TD (portion control). Pre-intervention and following the 3-week diet fMRI-FCR, functional connectivity, food cravings (Food Craving Inventory) and weight were considered. RESULTS: Compared to TD, TMR showed increased fMRI-FCR of the bilateral dorsolateral prefrontal (dlPFC), orbitofrontal, anterior cingulate, primary motor and left insular cortices and bilateral nucleus accumbens regions in the post-intervention state relative to the pre-intervention state. Compared to TD, TMR was also associated with negative modulation of fMRI-FCR of the nucleus accumbens, orbitofrontal cortex and amygdala by dlPFC. Reduced body weight (4.87 kg, P < 0.001), body fat (2.19 kg, P = 0.004) and overall food cravings (0.41, P = 0.047) were seen in the TMR group. In the TD group reduced body weight (2.37 kg, P = 0.004) and body fat (1.64 kg, P = 0.002) were noted. Weight loss was significantly greater in TMR versus TD (2.50 kg, P = 0.007). CONCLUSIONS: Greater weight loss and reduced cravings, coupled with stronger activations and potential negative modulation of the food reward related regions by the dlPFC during exposure to visual food cues is consistent with increased executive control in TMR vs. TD
Amygdala · Central nervous system · Cognition · Craving · Cue reactivity · Dorsolateral prefrontal cortex · Food craving · Functional magnetic resonance imaging · Meal · Nucleus accumbens · Orbitofrontal cortex · Prefrontal cortex · Diet and metabolism studies · Eating Disorders and Behaviors · Medicine · Neuroscience · Psychology · Regulation of Appetite and Obesity · Internal Medicine
Food reward
A global optimisation method for robust affine registration of brain images
‘Liking’ and ‘wanting’ food rewards
Weight-Loss Outcomes
Development and Validation of the Food‐Craving Inventory
Cortical Surface-Based Analysis
Fast robust automated brain extraction
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013
Neural control of appetite
Effects on food cravings of a very low calorie diet or a balanced, low calorie diet
Brain regions involved in ingestive behavior and related psychological constructs in people undergoing calorie restriction
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,13 |
| Citation span | 2018 - 2018 (1) |
| Citation velocity | historical |
| Highly cited | No |