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Diagnosing Mild Cognitive Impairment as a Precursor to Dementia

Fact or Fallacy

Bibliographic Data

ID11510089
AuthorsShannon Z Klekociuk (0000-0001-8654-2924, University of Tasmania), Nichole L Saunders (0000-0003-4609-114X, University of Tasmania), Mathew J Summers (0000-0002-3869-4920, University of Tasmania, corresponding author)
Year2016
Volume51
Issue5
Pages366-373
Publication date2016-06-16
Open AccessYes
TypeARTICLE
VenueAustralian Psychologist (JOURNAL)
Journal identifiersISSN: 0005-0067 • E-ISSN: 1742-9544
PublisherTaylor & Francis (PUBLISHER • GB)
DOI10.1111/ap.12178
OpenAlexW2531667517
LanguageEN
Citations received1
References cited64

Mild cognitive impairment (MCI) describes a period of subclinical cognitive decline associated with an increased risk for the development of Alzheimer's disease (AD). However, research groups have rapidly moved from defining MCI as a risk profile for AD, to promoting MCI as a clinical diagnosis without sufficient evidence of its validity as a diagnostic entity. Specifically, the criterion, subjective change in cognition, remains controversial in light of growing evidence that subjective reports are inadequate predictors of genuine cognitive impairment. Further, operationalisation of the cognitive impairment criterion varies widely across studies in terms of which domains are assessed, and how these domains are assessed. Many studies also fail to acknowledge the psychometric limitations of neuropsychological measures and how this may impact the diagnosis of MCI. In addition, recent research indicates that MCI is longitudinally unstable, with up to 48% of those diagnosed with MCI “recovering” to age appropriate levels of functioning over time. While the MCI concept as it is currently defined may be useful in terms of indicating a risk profile, its ability to sensitively and specifically identify those who will transition to a clinical state remains questionable

Cognition · Cognitive decline · Cognitive impairment · Dementia · Disease · Neuropsychology · Pathology · Psychiatry · Subclinical infection · Alzheimer's disease research and treatments · Blood Pressure and Hypertension Studies · Clinical Psychology · Dementia and Cognitive Impairment Research · Medicine · Psychology

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    Open Access•Bengt Winblad, Katie Palmer et al.•Journal of Internal Medicine•2004

  • The diagnosis of mild cognitive impairment due to Alzheimer's disease

    Open Access•Marilyn S Albert, Steven T DeKosky et al.•Alzheimer's & Dementia•2011

  • The diagnosis of dementia due to Alzheimer's disease

    Open Access•Guy M Mckhann, David S Knopman et al.•Alzheimer's & Dementia•2011

  • Mild cognitive impairment as a diagnostic entity

    Open Access•Ronald C Petersen•Journal of Internal Medicine•2004

  • Current Concepts in Mild Cognitive Impairment

    Ronald C Petersen, Rachelle S Doody et al.•Archives of Neurology•2001

Citations per year0.17
Citation span2020 - 2020 (1)
Highly citedNo

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