Association of High-Density Lipoprotein Cholesterol With Cognitive Function

Findings From the PROspective Study of Pravastatin in the Elderly at Risk

Bibliographic Data

ID12798997
AuthorsLeslie Grasset (0000-0003-2812-0103, University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team VINTAGE, Bordeaux, France), Roelof A J Smit (0000-0001-9822-6726, Department of Cardiology, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands), Michelle R Caunca (0000-0002-5177-9048, University of Miami), Tali Elfassy (0000-0002-7528-7988, University of Miami), Michelle C Odden (0000-0002-5974-3648, Stanford University), Jeroen van der Grond (0000-0002-0185-3158, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands), Mark A van Buchem (0000-0003-1881-1998, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands), David J Stott (0000-0002-3110-7746, University of Glasgow), Naveed Sattar (0000-0002-1604-2593, British Heart Foundation, Glasgow Cardiovascular Research Centre, University of Glasgow, UK), Stella Trompet (0000-0001-5006-0528, Department of Cardiology, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands), J Wouter Jukema (0000-0002-3246-8359, Department of Cardiology, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands), Adina Zeki Al Hazzouri (0000-0001-5398-3408, Columbia University, corresponding author)
Year2020
Volume32
Issue9
Pages1267-1274
Publication date2020-05-27
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Aging and Health (JOURNAL)
Journal identifiersISSN: 1552-6887 • E-ISSN: 0898-2643
PublisherSAGE Publishing (PUBLISHER • US)
DOI10.1177/0898264320916959
PMID32456512
OpenAlexW3031718344
LanguageEN
References cited39

Objective: We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. Method: We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. HDL-c variability was defined as the intraindividual standard deviation over each person's repeated measurements. Results: Higher HDL-c variability was associated with worse performance on the Letter-Digit Coding Test (β [95% confidence interval] [CI] = -4.39 [-7.36, -1.43], p = .004), immediate recall on the 15-Picture Learning Test (β [95% CI] = -0.98 [-1.86, -0.11], p = .027), and delayed recall on the 15-Picture Learning Test (β [95% CI] = -1.90 [-3.14, -0.67], p = .002). The associations did not vary by treatment group. Discussion: Our findings suggest that variability in HDL-c may be associated with poor cognitive function among older adults

California Verbal Learning Test · Cholesterol · Cognition · Confidence interval · Post-hoc analysis · Pravastatin · Prospective cohort study · Psychiatry · Verbal learning · Blood Pressure and Hypertension Studies · Hormonal Regulation and Hypertension · Lipoproteins and Cardiovascular Health · Medicine · Psychology · Internal Medicine

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