Characterization of the formulated cream and powder during the spray drying process of hebernem-s product
Bibliographic Data
| ID | 12945165 |
|---|---|
| Authors | Yunier Luis Paneque Díaz (Centro de Ingeniería Genética y Biotecnología), Rutdali María Segura Silva (Centro de Ingeniería Genética y Biotecnología), Nemecio González Fernández (Centro de Ingeniería Genética y Biotecnología), Jesus Zamora Sanchez (Centro de Ingeniería Genética y Biotecnología), Eikel Pérez González (0000-0001-9548-9301, Centro de Ingeniería Genética y Biotecnología), Lourdes Mariana Crespo Zafra (0000-0002-4799-3447, University of Camagüey), Aylín Nordelo Valdivia (Centro de Ingeniería Genética y Biotecnología), Amaury Pérez Sánchez (0000-0002-0819-6760, University of Camagüey) |
| Year | 2023 |
| Volume | 36 |
| Issue | 03 |
| Pages | 295-318 |
| Publication date | 2023-06-30 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Nexo Revista Científica (JOURNAL) |
| Journal identifiers | ISSN: 1818-6742 • E-ISSN: 1995-9516 |
| Publisher | Consejo Nacional de Rectores (PUBLISHER) |
| DOI | 10.5377/nexo.v36i03.16450 |
| OpenAlex | W4385197494 |
| Language | EN |
| Citations received | 1 |
| References cited | 1 |
Spray drying is increasingly investigated and widely applied in different industrial fields due to the diversity of the dried products that are obtained. In the present work, we determined the average diameter and area of Tsukamurella paurometabola C-924 cells contained in the formulated cream before the drying stage; the viability of the cream at different temperatures (10, 20 and 30 °C) and times (6, 15 and 24 hours); the diameter of HeberNem-S powder particles after spray drying; the stability of the HeberNem-S product at near ambient temperatures without applying vacuum conditions; and the adsorption isotherms of the HeberNem-S product. The area of the T. paurometabola cells had an average value of 3.154 μm2, while the average diameter was 3.208 μm. The average diameter of the dehydrated powder particles of the HeberNem-S product was 39.203 μm. In the temperature range from 10 to 30 °C, storage time has a greater influence than temperature on survival, while the survival is less than 0.9 after 10 hours of storage. In order for the HeberNem-S product to meet the quality specifications, it must be packaged in an environment with relative moisture less than 60
Chromatography · Freeze-drying · Spray drying · Vacuum drying · Chemistry · Inhalation and Respiratory Drug Delivery · Materials Science · Microencapsulation and Drying Processes
| Citations per year | 0.33 |
|---|---|
| Citation span | 2023 - 2023 (1) |
| Highly cited | No |