Enhancing MAFLD Care

Efficacy of a Multidisciplinary Community Intervention on Self-Management and Hepatic Outcomes

Dados Bibliográficos

ID13776342
AutoresHai Yong Cai (Peking University), Huan-Jing Cai (0009-0008-9037-9611, Peking University International Hospital, Beijing, China), Hailun Liang (0000-0002-9917-411X, Renmin University of China), Hai-Lun Liang (Renmin University of China, Beijing, China), Leiyu Shi (0000-0001-9227-0849, Johns Hopkins University, autor correspondente), Lei-Yu Shi (Johns Hopkins University Primary Care Policy Center, Baltimore, MD, USA), Yihui Rong (0000-0002-2300-160X, Peking University), Yi-Hui Rong (Peking University International Hospital, Beijing, China), Jing Li (0000-0001-7792-4322, Peking University International Hospital, Beijing, China), Yan Zhang (0000-0001-8460-2671, Peking University International Hospital, Beijing, China), Irum Zeb (0000-0001-5480-3990, Peking University International Hospital, Beijing, China), Ruifang Ma (0000-0002-3663-2240, Peking University), Rui-Fang Ma (Peking University International Hospital, Beijing, China)
Ano2025
Volume62
Páginas469580251380071-469580251380071
Data de publicação2025-09-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoINQUIRY The Journal of Health Care Organization Provision and Financing (JOURNAL)
Identificadores do periódicoISSN: 0046-9580 • E-ISSN: 1945-7243
EditoraSAGE Publishing (PUBLISHER • US)
DOI10.1177/00469580251380071
PMID41137547
OpenAlexW4415542322
IdiomaEN
Referências citadas54

Metabolic-associated fatty liver disease (MAFLD) is a prevalent condition associated with significant hepatic morbidity, yet evidence-based community interventions remain limited. This mixed-methods study first assessed self-management capacity and quality of life (QOL) among MAFLD patients (n = 218) in community settings, revealing suboptimal self-management (mean score 2.84 ± 0.73) and moderate QOL (3.23 ± 0.77), with education level and occupation identified as predictors. Subsequently, a randomized controlled trial (RCT) evaluated a novel community-based multidisciplinary intervention (nutritional counseling, behavioral coaching, clinical monitoring) versus standard education (n = 100). At 3-month follow-up, the intervention group demonstrated clinically significant improvements versus controls: greater weight reduction (-9.76 vs 0.11 kg; P = .028), body mass index (BMI) decrease (-3.01 vs 0.28 kg/m2; P = .006), and QOL enhancement (+8.97 vs. +2.83 points; P = .002). Significant metabolic and hepatic improvements included reduced liver steatosis (controlled attenuation parameter [CAP]: -29 dB/m; P = .001), lower liver enzymes (alanine aminotransferase [ALT]: -12 U/L, P = .039; aspartate aminotransferase [AST]: -5.5 U/L, P = .015), and decreased fasting glucose (-0.97 mmol/L; P = .026). This scalable multidisciplinary model effectively enhances self-management adherence, improves metabolic health and hepatic parameters, and boosts QOL in MAFLD, offering a resource-efficient strategy for reducing chronic disease burden in primary care

Body mass index · Fatty liver · Multidisciplinary approach · Psychological intervention · Quality of life (healthcare · Randomized controlled trial · Steatosis · Weight loss · Liver Disease and Transplantation · Liver Disease Diagnosis and Treatment · Pancreatitis Pathology and Treatment