The Relation between Changes in Vitamin D and Vitamin B12 Levels, Body Mass Index and Outcome in Methadone Maintenance Treatment Patients
Bibliographic Data
| ID | 13913360 |
|---|---|
| Authors | Elad Malik (Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel), Lihi Rozner (Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, corresponding author), Miriam Adelson (0009-0005-1649-6260, Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel), Shaul Schreiber (0000-0003-2254-7771, Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel), Einat Peles (Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel) |
| Year | 2020 |
| Volume | 53 |
| Issue | 1 |
| Pages | 55-64 |
| Publication date | 2020-11-03 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Psychoactive Drugs (JOURNAL) |
| Journal identifiers | ISSN: 0279-1072 • E-ISSN: 2159-9777 |
| Publisher | Taylor & Francis (PUBLISHER • GB) |
| DOI | 10.1080/02791072.2020.1840680 |
| PMID | 33143561 |
| OpenAlex | W3095666525 |
| Language | EN |
| References cited | 58 |
Patients' Body Mass Index (BMI) increase during methadone maintenance treatment (MMT), and both Vitamins D and B12 deficiencies may be associated with BMI. We studied the relations between BMI, these vitamins and treatment outcome in patients with opioid use disorder receiving MMT. Vitamin B12 levels were available for 272 patients and Vitamin D levels were available for 260 patients. Of those 112 and 80 respectively had two measures (at admission or thereafter, and while stabilized or after one year in treatment). Patients' BMI levels and long-term retention were analyzed. Vitamin B12 was lower in patients abusing cocaine/amphetamine on admission. Vitamin D did not change over time, but a significant weight gain could be observed in 38 patients whose vitamin D was elevated compared to 42 whose levels were not, (25.4 ± 4.8 to 28.8 ± 5.2 vs. 24.3 ± 3.7 to 25.5 ± 4.0, p(Time) p = .04). Longer cumulative retention was observed among the elevated vitamin D group (8.1 years, 95% CI 6.3-9.8) in comparison with the non-elevated group (4.8y 95% CI 3.6-6.1, Kaplan Meier, p = .02). Stimulants misuse was associated with low B12 levels. Vitamin D elevation is associated with weight gain and longer retention in treatment
Anesthesia · Body mass index · Body weight · Methadone · Methadone maintenance · Opioid · Vitamin · Vitamin B12 · Vitamin D and neurology · Weight gain · Folate and B Vitamins Research · Medicine · Neurological and metabolic disorders · Pharmacological Effects and Toxicity Studies · Endocrinology · Gastroenterology · Internal Medicine
| Highly cited | No |
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