Motivational Factors in Cocaine Pharmacotherapy Trials with Methadone-Maintained Patients
Problems and Paradoxes
Bibliographic Data
| ID | 14675975 |
|---|---|
| Authors | Arthur Margolin (a Department of Psychiatry , Yale University School of Medicine), S Kelly Avants (a Department of Psychiatry , Yale University School of Medicine), Bruce J Rounsaville (Yale University), Bruce Rounsaville (a Department of Psychiatry , Yale University School of Medicine), Thomas R Kosten (0000-0003-1505-555X, a Department of Psychiatry , Yale University School of Medicine), Richard S Schottenfeld (0000-0002-8601-0394, a Department of Psychiatry , Yale University School of Medicine) |
| Year | 1997 |
| Volume | 29 |
| Issue | 2 |
| Pages | 205-212 |
| Publication date | 1997-06-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Psychoactive Drugs (JOURNAL) |
| Journal identifiers | ISSN: 0279-1072 • E-ISSN: 2159-9777 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/02791072.1997.10400189 |
| PMID | 9250948 |
| OpenAlex | W2025309318 |
| Language | EN |
| References cited | 42 |
Phamacotherapy trials for cocaine abuse among methadone-maintained patients have typically reported negative findings as well as high rates of cocaine use during the trial. The contribution of motivational factors to these results is a potentially important, under investigated area. This article points out that some methadone-maintained patients may enter a trial for cocaine abuse with little desire for treatment, motivated primarily to continue receiving methadone or to avoid program sanctions for continued cocaine use. Participants in clinical trials may constitute a phase delaying discharge in a cyclic pattern of multiple treatment episodes. Testing a pharmacologic agent in a motivationally inappropriate sample may not provide a good estimate of the agent's effectiveness. In view of the important public health role that methadone maintenance programs play in preventing HIV transmission, and the subversion of this role by intravenous cocaine use, solutions to these problems are urgently needed. The authors suggest several possible approaches, including pre- and posttreatment motivation assessment, as well as the inclusion of psychosocial interventions that provide the context for the emergence of potential medication effects
Addiction · Clinical trial · Cocaine dependence · Drug · Euphoriant · Heroin · Methadone · Methadone maintenance · Psychiatry · Psychosocial · Substance abuse · Cannabis and Cannabinoid Research · Clinical Psychology · Medicine · Opioid Use Disorder Treatment · Psychology · Substance Abuse Treatment and Outcomes · Internal Medicine
The Effectiveness of Methadone Maintenance Treatment
The process of smoking cessation
Toward a Comprehensive Model of Change
A motivational model of alcohol use.
Intrinsic Motivation and Self-Determination in Human Behavior
Cocaine Abuse in Methadone Maintenance Programs
Stage of Change” by Drug Problem in Concurrent Opioid, Cocaine, and Cigarette Users
In search of how people change
The "What" and "Why" of Goal Pursuits
| Highly cited | No |
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