Cadmium exposure is associated with chronic kidney disease in a superfund site lead smelter community in Dallas, Texas
Bibliographic Data
| ID | 14679570 |
|---|---|
| Authors | Bertis B Little (0000-0002-6485-4641, University of Louisville, corresponding author), Bert B Little (University of Louisville), Giang T Vu (0000-0003-1159-6973, University of Central Florida), Bradley J Walsh (0000-0003-3571-4399, Parkland Health & Hospital System), Brad Walsh (Parkland Hospital and Health System, Dallas, TX, USA) |
| Year | 2023 |
| Volume | 50 |
| Issue | 1 |
| Pages | 360-369 |
| Publication date | 2023-01-02 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Annals of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0301-4460 • E-ISSN: 1464-5033 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/03014460.2023.2236017 |
| PMID | 37615209 |
| OpenAlex | W4386116091 |
| Language | EN |
| Citations received | 1 |
| References cited | 51 |
Background: The study was conducted in a Dallas lead smelter community following an Environmental Protection Agency (EPA) Superfund Cleanup project. Lead smelters operated in the Dallas community since the mid-1930s.Aim: To test the hypothesis that cadmium (Cd) exposure is associated with chronic kidney disease (CKD) ≥ stage 3.Subjects and methods: Subjects were African American residents aged ≥19 to ≤ 89 years (n=835). CKD ≥ stage 3 was predicted by blood Cd concentration with covariates.Results: In logistic regression analysis, CKD ≥ stage 3 was predicted by age ≥ 50 years (OR = 4.41, p < 0.0001), Cd level (OR = 1.89, p < .05), hypertension (OR = 3.15, p < 0.03), decades living in the community (OR = 1.34, p < 0.003) and T2DM (OR = 2.51, p < 0.01). Meta-analysis of 11 studies of Cd and CKD ≥ stage 3 yielded an ORRANDOM of 1.40 (p < 0.0001). Chronic environmental Cd exposure is associated with CKD ≥ stage 3 in a Dallas lead smelter community controlling covariates.Conclusion: Public health implications include screening for heavy metals including Cd, cleanup efforts to remove Cd from the environment and treating CKD with newer renal-sparing medications (e.g., SGLT-2 inhibitors, GLP-1s)
Biology · Cadmium · Environmental health · Hazardous waste · Kidney disease · Logistic regression · Superfund · Chemistry · Environmental Justice and Health Disparities · Heavy Metal Exposure and Toxicity · Heavy metals in environment · Medicine · Internal Medicine
Toxicity, mechanism and health effects of some heavy metals
A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine
Chronic Environmental and Occupational Lead Exposure and Kidney Function among African Americans
Low level exposure to cadmium increases the risk of chronic kidney disease
The fallacy of the ecological fallacy
| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |