Shexiang Tongxin Dropping Pills attenuate ischemic microvascular dysfunction via suppressing P66Shc-mediated mitochondrial respiration deficits
Bibliographic Data
| ID | 14726730 |
|---|---|
| Authors | Li Zhu (0000-0003-0179-6496, Guangzhou University of Chinese Medicine), Ru Huang (0000-0002-5124-1950, Guangzhou University of Chinese Medicine), Jing Feng (0000-0003-0594-090X, Guangzhou University of Chinese Medicine), Jing-Rui Feng, Miao Zhang (0009-0008-4320-6232, Guangzhou University of Chinese Medicine), Xiaojie Huang (0000-0002-5045-9202, Guangzhou University of Chinese Medicine), Xiao-jie Huang, Zeyu Chen (0000-0003-2449-188X, Guangzhou University of Chinese Medicine), Wei Wang (0000-0001-5806-2368), Wei Wanga (Guangzhou University of Chinese Medicine, corresponding author), Yang Chen (0000-0001-5943-3247, Guangzhou University of Chinese Medicine, corresponding author) |
| Year | 2025 |
| Volume | 346 |
| Pages | 119664 |
| Publication date | 2025-04-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.119664 |
| PMID | 40154895 |
| OpenAlex | W4408933279 |
| Language | EN |
| References cited | 49 |
STDP facilitated CSE expression and promoted H 2 S production, contributing to the inactivation of P66shc by suppressing its expression and increasing its sulfhydration. This process impeded P66Shc translocation to mitochondria, subsequently restoring mitochondrial respiration and alleviating IS-induced cerebral microvascular endothelial dysfunction
Biology · Cardiology · Mitochondrion · Pill · Respiration · Healthcare and Venom Research · Medicine · Neurological Disease Mechanisms and Treatments · Traditional Chinese Medicine Studies · Anatomy · Biochemistry · Pharmacology
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Shexiang Tongxin dropping pills protect against ischemic stroke-induced cerebral microvascular dysfunction via suppressing TXNIP/NLRP3 signaling pathway
Huangqi−Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats
| Citation velocity | historical |
|---|---|
| Highly cited | No |