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An O-methylflavone from Artemisia afra kills non-replicating hypoxic Mycobacterium tuberculosis

Bibliographic Data

ID14728745
AuthorsJoshua J Kellogg (0000-0001-8685-0353, Pennsylvania State University, corresponding author), Maria Natalia Alonso (0000-0001-8416-1482, Worcester Polytechnic Institute), R Teal Jordan (0009-0006-5869-1336, Pennsylvania State University), Junpei Xiao (0000-0002-7790-9875, Worcester Polytechnic Institute), Juan Hilario Cafiero (0000-0002-7976-7276, Worcester Polytechnic Institute), Trevor Bush (Worcester Polytechnic Institute), Xiaoling Chen (0000-0002-2271-1140, Pennsylvania State University), Melissa Towler, Melissa J Towler (Worcester Polytechnic Institute), Pamela J Weathers (0000-0001-5138-3839, Worcester Polytechnic Institute), Pamela Weathers, Scarlet S Shell (0000-0003-1136-1728, Worcester Polytechnic Institute, corresponding author)
Year2024
Volume333
Pages118500
Publication date2024-10-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118500
PMID38944359
OpenAlexW4400088686
LanguageEN
References cited43

The present study demonstrated that an O-methylflavone constituent of Artemisia afra explains part of the activity of this plant against Mtb. This result contributes to a mechanistic understanding of the reported anti-tubercular activity of A. afra and highlights the need for further study of this traditional medicinal plant and its active compounds

Biology · Mycobacterium tuberculosis · Pathology · Traditional medicine · Tuberculosis · Medicine · Microbial Natural Products and Biosynthesis · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology · Microbiology

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