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Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro

Bibliographic Data

ID14729335
AuthorsNdeye F Kane (Worcester Polytechnic Institute, corresponding author), Bushra Hafeez Kiani (0000-0003-0748-9745, Worcester Polytechnic Institute), Matthew R Desrosiers (0000-0001-6510-0414, Worcester Polytechnic Institute), Melissa J Towler (Worcester Polytechnic Institute), Pamela J Weathers (0000-0001-5138-3839, Worcester Polytechnic Institute)
Year2022
Volume298
Pages115587
Publication date2022-11-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2022.115587
PMID35934190
OpenAlexW4289856660
LanguageEN
Citations received2
References cited38

Artemisia · Artemisia annua · Artemisinin · CYP2B6 · CYP3A4 · Cytochrome P450 · Dihydroartemisinin · Enzyme · Malaria · Plasmodium falciparum · Traditional medicine · Chemistry · Drug-Induced Hepatotoxicity and Protection · Medicine · Pharmacogenetics and Drug Metabolism · Pharmacological Effects of Natural Compounds · Biochemistry · Immunology · Pharmacology

  • Differential synergistic antimalarial effects of an A. annua extract on artemisinin via host pharmacokinetic modulation

    Open Access•Kun Xu, Yuewu Xie et al.•Journal of Ethnopharmacology•2026

  • An O-methylflavone from Artemisia afra kills non-replicating hypoxic Mycobacterium tuberculosis

    Open Access•Joshua J Kellogg, Maria Natalia Alonso et al.•Journal of Ethnopharmacology•2024

  • Artemisinin permeability via Caco-2 cells increases after simulated digestion of Artemisia annua leaves

    Open Access•Matthew R Desrosiers, Pamela J Weathers•Journal of Ethnopharmacology•2018

  • Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice

    Open Access•Pamela J Weathers, Mostafa A Elfawal et al.•Journal of Ethnopharmacology•2014

  • Investigation of the component in Artemisia annua L. leading to enhanced antiplasmodial potency of artemisinin via regulation of its metabolism

    Open Access•Tian-Yu Cai, Tianyu Cai et al.•Journal of Ethnopharmacology•2017

  • Artemisia afra, a controversial herbal remedy or a treasure trove of new drugs

    Open Access•Anneke du Toit, Frank van der Kooy•Journal of Ethnopharmacology•2019

  • Effect of leaf digestion and artemisinin solubility for use in oral consumption of dried Artemisia annua leaves to treat malaria

    Open Access•Matthew R Desrosiers, Pamela J Weathers•Journal of Ethnopharmacology•2016

Citations per year1
Citation span2024 - 2026 (3)
Highly citedNo

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