Total flavonoids isolated from Fructus Mume (Prunus mume Sieb. et Zucc.) mitigate Parkinson's disease progression by promoting neuronal mitophagy via activation of the CaMKKβ/AMPK signaling pathway
Bibliographic Data
| ID | 14729808 |
|---|---|
| Authors | Chunling Wang (0000-0002-8622-8465, Guangxi University), Xiaotao Feng (Guangxi University), Wentao Zhang (0000-0001-6340-7551, Guangxi University), Lizhen Huang (0000-0001-6397-9111, Guangxi University), Xiangdong Lu (0000-0002-9199-8675, Ruikang Affiliated Hospital of Guangxi Medical University), Mengjie Sun (0000-0003-0506-2721, Ruikang Affiliated Hospital of Guangxi Medical University), Mengyuan Gao (0000-0001-9446-2879, Ruikang Affiliated Hospital of Guangxi Medical University), Xiaodong Wen (0009-0005-6848-7454, Ruikang Affiliated Hospital of Guangxi Medical University, corresponding author) |
| Year | 2026 |
| Volume | 361 |
| Pages | 121244 |
| Publication date | 2026-04-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2026.121244 |
| PMID | 41564984 |
| OpenAlex | W7124827487 |
| Language | EN |
| References cited | 55 |
FMF promotes neuronal mitophagy to exert the neuroprotective effects by activating the CaMKKβ/AMPK signaling pathway. These findings provide a theoretical foundation for the application of FM in the treatment of PD and promote the clinical application of FM
Apoptosis · Autophagy · Disease · Mitophagy · Neuroprotection · Pharmacognosy · Signal pathway · Signal transduction · Bioactive Compounds in Plants · Neurological Disease Mechanisms and Treatments · Parkinson's Disease Mechanisms and Treatments
| Highly cited | No |
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