Effect of Zembrin ® and four of its alkaloid constituents on electric excitability of the rat hippocampus
Bibliographic Data
| ID | 14729856 |
|---|---|
| Authors | Wilfried Dimpfel (0000-0002-9930-6733, Justus-Liebig-Universität Gießen, corresponding author), Richard Franklin, Richard A Franklin (0000-0003-0299-9578), Nigel Gericke (0000-0003-4212-1487), Leonie Schombert |
| Year | 2018 |
| Volume | 223 |
| Pages | 135-141 |
| Publication date | 2018-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2018.05.010 |
| PMID | 29758341 |
| OpenAlex | W2804322092 |
| Language | EN |
| Citations received | 5 |
| References cited | 23 |
We have discovered a new structure activity relationship for Sceletium alkaloids. Since attenuation of AMPA mediated transmission has been related to successful adjunctive treatment of epileptic patients), Mesembrenol and Mesembranol may serve as new chemical leads for the development of new drugs for the treatment of epilepsy
Alkaloid · AMPA receptor · Anesthesia · Anticonvulsant · Biology · Epilepsy · Glutamate receptor · Hippocampus · In vivo · Kindling · Long-term potentiation · Pentylenetetrazol · Population · Psychiatry · Receptor · Stereochemistry · Stimulation · Alkaloids: synthesis and pharmacology · Chemical synthesis and alkaloids · Chemistry · Cholinesterase and Neurodegenerative Diseases · Medicine · Internal Medicine · Pharmacology
Sceletium tortuosum
Sceletium tortuosum
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| Citations per year | 1 |
|---|---|
| Citation span | 2021 - 2025 (5) |
| Highly cited | No |