Nigel Gericke
Biographic Data
| ID | 7264598 |
|---|---|
| NAME | Nigel Gericke |
| GIVEN NAMES | Nigel |
| FAMILY NAME | Gericke |
| SIGNATURE | GERICKE N |
| AFFILIATIONS | University of Johannesburg |
| ORCID | 0000-0003-4212-1487 |
| VERIFIED | No |
| TOTAL WORKS | 6 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 6 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2008 |
| LATEST PUBLICATION YEAR | 2020 |
| H-INDEX | 0 |
Central nervous system activities of extract Mangifera indica L
Mangiferin is a COMT inhibitor of moderate potency and is the major CNS-active compound in MLE. Both mangiferin and MLE increase hippocampal LTP in-vitro, and induce a similar pattern of changes in brain electrical activity in-vivo. While the translational clinical trials of MLE are limited by being single dose studies in a small number of subjects, they provide the first clinical evidence that the extract is well tolerated with no cardiovascular…
Effect of Zembrin ® and four of its alkaloid constituents on electric excitability of the rat hippocampus
We have discovered a new structure activity relationship for Sceletium alkaloids. Since attenuation of AMPA mediated transmission has been related to successful adjunctive treatment of epileptic patients), Mesembrenol and Mesembranol may serve as new chemical leads for the development of new drugs for the treatment of epilepsy
Electropharmacogram of Sceletium tortuosum extract based on spectral local field power in conscious freely moving rats
The combined results from the electropharmacograms and comparative discriminatory analyses suggest that Zembrin® has dose dependent activity, with potential applications as a cognitive function enhancer, as an antidepressant, and as an analgesic
Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens
Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids
Sceletium—A review update
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Sceletium—A review update
Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids
Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens
Electropharmacogram of Sceletium tortuosum extract based on spectral local field power in conscious freely moving rats
The combined results from the electropharmacograms and comparative discriminatory analyses suggest that Zembrin® has dose dependent activity, with potential applications as a cognitive function enhancer, as an antidepressant, and as an analgesic
Effect of Zembrin ® and four of its alkaloid constituents on electric excitability of the rat hippocampus
We have discovered a new structure activity relationship for Sceletium alkaloids. Since attenuation of AMPA mediated transmission has been related to successful adjunctive treatment of epileptic patients), Mesembrenol and Mesembranol may serve as new chemical leads for the development of new drugs for the treatment of epilepsy
Central nervous system activities of extract Mangifera indica L
Mangiferin is a COMT inhibitor of moderate potency and is the major CNS-active compound in MLE. Both mangiferin and MLE increase hippocampal LTP in-vitro, and induce a similar pattern of changes in brain electrical activity in-vivo. While the translational clinical trials of MLE are limited by being single dose studies in a small number of subjects, they provide the first clinical evidence that the extract is well tolerated with no cardiovascular…
Medicine (6 works) · Biology (5 works) · Traditional medicine (5 works) · Chemical synthesis and alkaloids (4 works) · Botany (3 works) · Cholinesterase and Neurodegenerative Diseases (3 works) · Pharmacology (3 works) · Hippocampus (2 works) · In vivo (2 works) · Internal Medicine (2 works)