Central nervous system activities of extract Mangifera indica L
Bibliographic Data
| ID | 14730716 |
|---|---|
| Authors | Laura López-Ríos (0000-0002-9386-5593), Julia C Wiebe, J Wiebe (0000-0001-8351-977X, corresponding author), Tanausú Vega-Morales (0000-0002-3357-6028), Nigel Gericke (0000-0003-4212-1487, University of Johannesburg) |
| Year | 2020 |
| Volume | 260 |
| Pages | 112996 |
| Publication date | 2020-10-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2020.112996 |
| PMID | 32473365 |
| OpenAlex | W3029159281 |
| Language | EN |
| References cited | 46 |
Mangiferin is a COMT inhibitor of moderate potency and is the major CNS-active compound in MLE. Both mangiferin and MLE increase hippocampal LTP in-vitro, and induce a similar pattern of changes in brain electrical activity in-vivo. While the translational clinical trials of MLE are limited by being single dose studies in a small number of subjects, they provide the first clinical evidence that the extract is well tolerated with no cardiovascular side-effects, can induce changes in brain electrical activity, may give a faster reaction time, and decrease fatigue. These CNS activities support the reported folk-uses use of mango leaf tea as a substitute for tea and as a traditional remedy for fatigue and exhaustion. Extract Mangifera indica L., Zynamite, has nootropic potential, and larger clinical studies are needed to realise this potential
Biology · Botany · Hippocampus · In vivo · Mangifera · Mangiferin · Traditional medicine · Mangiferin and Mango Extracts · Medicine · Biotechnology · Internal Medicine · Pharmacology
| Highly cited | No |
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