Neuroprotective role of Da Qin Jiu decoction in ischemic stroke

Mitochondrial rescue through PI3K/Akt-mediated UPRmt activation

Bibliographic Data

ID14730873
AuthorsJing Luo (0000-0001-5193-3036, Chongqing Medical University), Jing Jing Luo (0000-0002-2784-1622), Yaling Zheng (Chongqing Medical University), Jialei Chen (0009-0003-9259-5936, Chongqing Medical University), Xin Xiong (0000-0003-0902-7886, The Affiliated Yongchuan Hospital of Chongqing Medical University), Jiashu Shen (0000-0001-6215-7386, Oxford BioMedica (United Kingdom)), Dou Hong (0009-0000-6281-7532, University of Oxford), Ning Jiang (0000-0003-1373-7995, Chongqing Medical University), Wenlu Li (0009-0000-2289-0647, Massachusetts General Hospital, corresponding author), Jing Zhao (0009-0008-1906-5396, Chongqing Medical University, corresponding author), Jingxian Wu (0000-0002-9588-814X, Chongqing Medical University, corresponding author)
Year2025
Volume343
Pages119433
Publication date2025-03-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119433
PMID39894416
OpenAlexW4407058990
LanguageEN
Citations received2
References cited45

DQJD exerts neuroprotective effects in IS by restoring mitochondrial function through UPR mt activation via the PI3K/Akt pathway. These findings support further exploration of DQJD as a therapeutic option for IS

Apoptosis · Biology · Cardiology · Decoction · Ischemia · Ischemic stroke · Neuroprotection · PI3K/AKT/mTOR pathway · Protein kinase B · Stroke (engine · Traditional medicine · Medicinal Plants and Bioactive Compounds · Medicine · Neurological Disease Mechanisms and Treatments · Neuroscience · Traditional Chinese Medicine Analysis · Biochemistry · Pharmacology

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