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Ethnomedicine, phytochemistry, pharmacology, pharmacokinetics, and clinical application of Salvia miltiorrhiza Bunge (Lamiaceae)

A comprehensive review

Bibliographic Data

ID14732608
AuthorsTingting Lan (0000-0002-4865-4092, Nanjing University of Chinese Medicine), Daixin Yu, Dai-Xin Yu (Nanjing University of Chinese Medicine), Qingrong Zhao (Nanjing University of Chinese Medicine), Cheng Qu (0000-0002-9012-1302, Nanjing University of Chinese Medicine, corresponding author), Qinan Wu (0000-0002-7836-0941, Nanjing University of Chinese Medicine, corresponding author)
Year2025
Volume350
Pages120032
Publication date2025-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120032
PMID40419206
OpenAlexW4410707385
LanguageEN
Citations received5
References cited189

Alternative medicine · Biological activity · Biology · Ethnomedicine · Lamiaceae · Medicinal plants · Pharmacognosy · Phytochemistry · Salvia · Salvia miltiorrhiza · Traditional Chinese medicine · Traditional medicine · Biological and pharmacological studies of plants · Medicine · Phytochemical Studies and Bioactivities · Traditional Chinese Medicine Analysis · Pharmacology

  • Ethnobotanical diversity of the genus Salvia L. (Lamiaceae)

    Open Access•Alexandru Nicolescu, Oleg Frumuzachi et al.•Journal of Ethnopharmacology•2026

  • Salvia miltiorrhiza Bunge alleviates pulmonary fibrosis by promoting fibroblast mitophagy

    Open Access•Xing Zhang, Xi Zhang et al.•Journal of Ethnopharmacology•2026

  • Traditional Chinese medicine in acne treatment

    Open Access•Jie Gong, Jiahao Zhang et al.•Journal of Ethnopharmacology•2026

  • Multitargeted synergistic mechanisms of Salvia miltiorrhiza and its bioactive compounds

    Open Access•Yue Wang, Yihang Wang et al.•Journal of Ethnopharmacology•2026

  • Therapeutic potential of pharmacological components of Salvia miltiorrhiza against atherosclerosis

    Open Access•Jin Zhang, Xiaoning Sun et al.•Journal of Ethnopharmacology•2026

  • Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose

    Open Access•Jing Zhou, Long Zhang et al.•Journal of Ethnopharmacology•2020

  • Efficacy of add-on Danhong injection in patients with unstable angina pectoris

    Open Access•Lin Chen, Guang Fu et al.•Journal of Ethnopharmacology•2022

  • Effects of salvianolic acid B and tanshinone IIA on the pharmacokinetics of losartan in rats by regulating the activities and expression of CYP3A4 and CYP2C9

    Open Access•Rong Wang, Hai Zhang et al.•Journal of Ethnopharmacology•2016

  • Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages

    Open Access•Haimei Liu, Shuli Ma et al.•Journal of Ethnopharmacology•2018

  • Pharmacokinetic study of salvianolic acid A in beagle dog after oral administration by a liquid chromatography–mass spectrometry method

    Open Access•Jialin Sun, Li Zhang et al.•Journal of Ethnopharmacology•2013

  • Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats

    Open Access•Yu-xiang Fei, Siqi Wang et al.•Journal of Ethnopharmacology•2017

  • In vivo distribution and pharmacokinetics of multiple active components from Danshen and Sanqi and their combination via inner ear administration

    Open Access•Wei Long, Shi-chang Zhang et al.•Journal of Ethnopharmacology•2014

  • Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells

    Open Access•Xiaxia Fan, Lichao Zhang et al.•Journal of Ethnopharmacology•2023

  • Investigation of Danshen and related medicinal plants in China

    Open Access•Minhui Li, Min-Hui Li et al.•Journal of Ethnopharmacology•2008

  • Salvianolic acid A from Danhong Injection induces vasorelaxation by Regulating L-type calcium channel in isolated mouse arteries

    Open Access•Yi-ke Lin, Yijun Chen et al.•Journal of Ethnopharmacology•2022

  • Chinese medicine GeGen-DanShen extract protects from myocardial ischemic injury through promoting angiogenesis via up-regulation of Vegf/VEGFR2 signaling pathway

    Open Access•Shuo Zhai, Xiaofan Zhang et al.•Journal of Ethnopharmacology•2021

  • Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease

    Open Access•Fan Xie, Bingcai Zhang et al.•Journal of Ethnopharmacology•2021

  • Anxiolytic effect of an extract of Salvia miltiorrhiza Bunge (Danshen) in mice

    Open Access•Yu-Shih Lin, Yu‐Shih Lin et al.•Journal of Ethnopharmacology•2021

  • Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia

    Open Access•Shan He, Tianqi Wang et al.•Journal of Ethnopharmacology•2022

  • A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease

    Open Access•Mingya Ding, Wenfang Ma et al.•Journal of Ethnopharmacology•2019

  • Study on therapeutic mechanism of total salvianolic acids against myocardial ischemia-reperfusion injury based on network pharmacology, molecular docking, and experimental study

    Open Access•Shuang Hu, Jing Wen et al.•Journal of Ethnopharmacology•2024

  • Acute and sub-chronic toxicity studies of Danshen injection in Sprague-Dawley rats

    Open Access•Meng Wang, Jin Liu et al.•Journal of Ethnopharmacology•2012

  • Evaluation of the anti-inflammatory activities of tanshinones isolated from Salvia miltiorrhiza var. alba roots in THP-1 macrophages

    Open Access•Shuli Ma, Dawei Zhang et al.•Journal of Ethnopharmacology•2016

  • Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway

    Open Access•Zhuo Xu, Ke Cai et al.•Journal of Ethnopharmacology•2024

  • Deer sinew with medicine and food homology

    Open Access•Rui Du, Li Sun et al.•Journal of Ethnopharmacology•2025

Unique citing works5
Citations per year5
Citation span2026 - 2026 (1)
Citation velocitycurrent
Highly citedNo
Citation typesNeutral: 4

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