Therapeutic potential of pharmacological components of Salvia miltiorrhiza against atherosclerosis

A preclinical systematic review and meta-analysis

Bibliographic Data

ID14745349
AuthorsJin Zhang (0000-0002-1374-598X, Chinese Academy of Medical Sciences & Peking Union Medical College), Xiaoning Sun (0000-0001-5797-2124, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine), Qingqing Wang (0000-0002-8418-5481, Chinese Academy of Medical Sciences & Peking Union Medical College), Ziyi Sun (0000-0001-7668-2421, Shandong University of Traditional Chinese Medicine), Wenjie Liu (0000-0001-7588-9295, Chinese Academy of Medical Sciences & Peking Union Medical College), Mengwen Huang (Chinese Academy of Medical Sciences & Peking Union Medical College), Lingyan Jiang (0009-0006-7523-6968, Chinese Academy of Medical Sciences & Peking Union Medical College), Kuiwu Yao (0000-0003-4087-7651, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author)
Year2026
Volume363
Pages121294
Publication date2026-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121294
PMID41690432
OpenAlexW7128683589
LanguageEN
References cited45

The pharmacological components of Salvia miltiorrhiza attenuate AS by regulating lipid metabolism, anti-inflammatory and antioxidant actions, improving endothelial function, modulating of vascular smooth muscle cells, remodeling extracellular matrix, and regulating programmed cell death. These findings provide translational insights that pave the way for subsequent preclinical and early-clinical studies, pending systematic validation through more rigorous research

Biological activity · Extracellular · Pharmacognosy · Phytotherapy · Salvia · Salvia miltiorrhiza · Smooth muscle · Vascular smooth muscle · Atherosclerosis and Cardiovascular Diseases · Cardiac Fibrosis and Remodeling · Traditional Chinese Medicine Analysis

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