Membrane-disrupting antibacterial activity of Artocarpus lacucha bark extract

A mechanistic study through experimental and computational approaches

Bibliographic Data

ID14733709
AuthorsTanmoy Banerjee (0000-0002-1701-501X, Jadavpur University), Arnab Sarkar (0000-0002-7354-2092, Jadavpur University), Rajdeep Saha (0000-0003-1440-763X, Birla Institute of Technology, Mesra), Shuvam Sar (0009-0004-2321-9467, Jadavpur University), Akash De (Jadavpur University), Amit Kumar Halder (0000-0002-4818-9047, CDA College), Biswatrish Sarkar (0000-0002-4268-301X, Birla Institute of Technology, Mesra), Parthasarathi Panda (0000-0003-0071-708X, DSMS Group of Institutions), Sanmoy Karmakar (0000-0003-2162-5061, Jadavpur University), Nilanjan Ghosh (0000-0002-7217-243X, Jadavpur University, corresponding author)
Year2026
Volume357
Pages120904
Publication date2026-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120904
PMID41242511
OpenAlexW4416345351
LanguageEN
References cited74

This integrative study demonstrates that the hexane extract of A. lacucha bark exhibits promising antibacterial action, and its putative mechanism could be direct membrane disruption, along with possible FabH inhibition, thereby validating its traditional use. The findings highlight the potential of A. lacucha as a promising source of natural antibacterial agents and underscore the importance of integrating ethnopharmacological knowledge with modern mechanistic insights to address the growing threat of antimicrobial resistance

Antibacterial activity · Antibacterial agent · Antimicrobial · Bacteria · Bark (sound · Mechanism (biology · Pharmacognosy · Bioactive natural compounds · Natural Compound Pharmacology Studies · Phytoestrogen effects and research

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