The ameliorating effects of tokishakuyakusan in a rat model of implantation failure involves endometrial gland leukemia inhibitory factor and decidualization

Bibliographic Data

ID14733778
AuthorsKiyoshi Terawaki (0000-0002-7309-8809, Tsumura Research Institute (Japan), corresponding author), Yayoi Saegusa (0000-0002-4801-6429, Tsumura Research Institute (Japan)), Kyoji Sekiguchi (Tsumura Research Institute (Japan)), Tomofumi Shimizu (0000-0001-8846-478X, Tsumura Research Institute (Japan)), Mikina Takiyama (0000-0002-8816-4223, Tsumura Research Institute (Japan)), Takashi Matsumoto (0000-0002-6899-1686, Tsumura Research Institute (Japan)), Seiichi Iizuka (0000-0001-5486-884X, Tsumura Research Institute (Japan)), Chinami Matsumoto (0009-0003-4208-6463, Tsumura Research Institute (Japan)), Fukuhito Motoyama
Year2021
Volume265
Pages113288
Publication date2021-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2020.113288
PMID32841695
OpenAlexW3080936639
LanguageEN
Citations received2
References cited50

The mechanism whereby TSS ameliorates RU-486-induced implantation failure in rats may involve the alleviation of decreased LIF production derived from the endometrial gland, and a dysfunction of decidualization, including lower progesterone responsiveness in the model. These findings may partly contribute to the interpretation of the beneficial effects of TSS on infertility

Andrology · Biology · Cytokine · Decidua · Decidualization · Endometrium · Fetus · Implantation failure · Infertility · Interleukin 6 · Leukemia inhibitory factor · Mifepristone · Pregnancy · Endometriosis Research and Treatment · Estrogen and related hormone effects · Medicine · Reproductive System and Pregnancy · Endocrinology · Internal Medicine

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