Quantitative evaluation of in vitro effects and interactions of active fractions in a Chinese medicinal formula (Yaotongning Capsule) on rat chondrocytes
Bibliographic Data
| ID | 14735156 |
|---|---|
| Authors | Liguo Zhang (0000-0002-3814-7783, East China University of Science and Technology), Li-Guo Zhang, Xiao-Wen Ouyang, Xiaowen Ouyang (East China University of Science and Technology), Ting-Ting Wu (East China University of Science and Technology), Li-Jun Ni, Lijun Ni (0000-0002-5957-0249, East China University of Science and Technology, corresponding author), Wan-Zhong Shi, Wanzhong Shi (0000-0003-0207-708X, Shuguang Hospital, corresponding author) |
| Year | 2014 |
| Volume | 155 |
| Issue | 3 |
| Pages | 1424-1432 |
| Publication date | 2014-09-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2014.07.011 |
| PMID | 25043778 |
| OpenAlex | W2090787589 |
| Language | EN |
| Citations received | 1 |
| References cited | 18 |
The YTNC formula is reasonable and has advantage in promoting the proliferation and GAG synthesis in IL-1β induced chondrocytes. YTNC׳s vehicle Chinese rice wine plays an important role in strengthening the activity of YTNC. YTNC may have the potential activity on treating chondrocytes degeneration caused by OA. However, the formula still can be simplified based on the combination of alkaloids, flavonoids and 50% of saponins from Glycyrrhiza uralensis to improve its quality controllability and safety. The present study can be a quite purposeful work for developing new YTNC-based formulas with maximal therapeutic efficacy and minimal adverse effects
Active compound · Active ingredient · Active principle · Biology · Botany · Capsule · Glycosaminoglycan · In vitro · Medicinal herbs · Stereochemistry · Traditional medicine · Chemistry · Medicinal Plant Pharmacodynamics Research · Medicine · Natural product bioactivities and synthesis · Pharmacological Effects of Natural Compounds · Biochemistry · Pharmacology
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| Citations per year | 0.1 |
|---|---|
| Citation span | 2016 - 2016 (1) |
| Highly cited | No |