Engeletin attenuates the inflammatory response via inhibiting TLR4-NFκB signaling pathway in Crohn's disease-like colitis
Bibliographic Data
| ID | 14736286 |
|---|---|
| Authors | Ziyun Wei (0000-0001-8913-1389, China Medical University), Xiao Ni (0000-0002-8159-9275, China Medical University), He Cui (0000-0001-6277-9804, China Medical University), Chang Shu (0000-0002-7880-9681, China Medical University), Yuxuan Peng (0000-0001-7874-1368, China Medical University), Jieyu Liu (0000-0001-8330-5376, China Medical University, corresponding author), Yunwei Li (0000-0002-5410-4505, First Hospital of China Medical University, corresponding author) |
| Year | 2025 |
| Volume | 336 |
| Pages | 118733 |
| Publication date | 2025-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.118733 |
| PMID | 39181281 |
| OpenAlex | W4401831743 |
| Language | EN |
| Citations received | 2 |
| References cited | 41 |
ENG has been proven to alleviate inflammation and ameliorate the damage of epithelial barrier in CD-like colitis. ENG also suppressed the M1 macrophages polarization and the inhibited inflammatory cytokines. TLR4-NFκB signaling pathway, especially TLR4, may be the target of ENG. These data offer a new insight into the therapeutic mechanisms of ENG
Colitis · Crohn's disease · Disease · Inflammation · Inflammatory response · NF-κB · Rhizome · TLR4 · Traditional medicine · IL-33, ST2, and ILC Pathways · Immune Response and Inflammation · Inflammatory Bowel Disease · Medicine · Immunology · Internal Medicine
Smilax china L. polyphenols inhibit LPS-induced macrophage M1 polarization to alleviate inflammation through NF-κB signaling pathway in vitro and in vivo
Shen-Ling-Bai-Zhu-San alleviates Crohn's disease-like colitis by modulating fatty acid degradation via the peroxisome proliferation-activated receptor pathway
The Nuclear Factor NF- B Pathway in Inflammation
Mesua assamica (King & Prain) kosterm. bark ethanolic extract attenuates rheumatoid arthritis via down-regulating TLR4/NF-κB/COX-2/iNOS and activation of Nrf2/HO-1 pathways
Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota
Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota
The flavonoid-enriched extract from the root of Smilax china L. inhibits inflammatory responses via the TLR-4-mediated signaling pathway
Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-κB pathway
| Citations per year | 2 |
|---|---|
| Citation span | 2025 - 2025 (1) |
| Highly cited | No |