A TCM formula assists temozolomide in anti-melanoma therapy by suppressing the STAT3 signaling pathway

Datos Bibliográficos

ID14736346
AutoresLu Wang (0000-0002-9250-3988, Affiliated Hospital of Shaanxi University of Chinese Medicine), Wang Lu (0000-0003-1425-192X), Tingting Huang (0000-0002-5058-1865, Northwest University), Huang Tingting, Long Kaihua, Kaihua Long (Shaanxi Provincial Hospital of Traditional Chinese Medicine), Wang Yuan (0000-0003-3565-9190), Yuan Wang (0000-0003-1439-5288, Shaanxi Provincial Hospital of Traditional Chinese Medicine), Yang Liu (0000-0003-1220-7044, Shaanxi Provincial Hospital of Traditional Chinese Medicine), Liu Yang (0000-0003-3048-3392), Li Ye (0000-0003-0401-5691, Shaanxi Provincial Hospital of Traditional Chinese Medicine), Yuxi Liu (0000-0003-2484-151X, Shaanxi Provincial Hospital of Traditional Chinese Medicine, autor de correspondencia), Liu Yuxi, Hong Zhang (0000-0003-2057-8427, Shaanxi Provincial Hospital of Traditional Chinese Medicine, autor de correspondencia), Zhang Hong (0000-0001-7253-2637)
Año2025
Volumen337
NúmeroPt 1
Páginas118810
Fecha de publicación2025-01-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaJournal of Ethnopharmacology (JOURNAL)
Identificadores de la revistaISSN: 0378-8741 • E-ISSN: 1872-7573
EditorialElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118810
PMID39255877
OpenAlexW4402343799
IdiomaEN
Referencias citadas23

Synergistic anti-melanoma effects of SLE/TMZ have been observed in animal and cellular models. One of the mechanisms of SLE/TMZ that underlies its anti-melanoma actions is inhibition of the STAT3 pathway. This work offers pre-clinical pharmacological backing for the advancement of SLE as a therapeutic agent to be used in conjunction with TMZ for the treatment of melanoma

Biology · Chemotherapy · Melanoma · Signal transduction · STAT3 · Temozolomide · Toxicity · Traditional medicine · Cancer Mechanisms and Therapy · Cytokine Signaling Pathways and Interactions · Medicine · Melanoma and MAPK Pathways · Cancer Research · Internal Medicine · Oncology · Pharmacology